Human MFAP3 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB10798R Datasheet / COA / SDS

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FAB10798R-100UG

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All MFAP3 Antibodies

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Human MFAP3 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human MFAP3 in direct ELISA.

Source

Monoclonal Mouse IgG1 Clone # 1059216

Purification

Protein A or G purified

Immunogen

Human embryonic kidney cell, HEK293-derived human MFAP3
Leu22-Met147
Accession # P55082

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: MFAP3

Microfibril-associated glycoprotein 3 (MFAP3), is a member of the MFAP family which play a role in microfibril assembly, elastinogenesis, and tissue homeostasis. The family members were identified as potential components of fibrillin-containing microfibrils, but they do not share structural similarities (1). MFAP3 is found in ocular zonules. Human MFAP3 is a serine-rich acidic protein located in zonular fibers and consists of an extracellular domain (ECD) containing one Ig-like C2-type domain, a single transmembrane domain, and a cytoplasmic domain. Within the ECD, mature human MFAP3 shares 74% amino acid sequence identity with mouse and rat MFAP3. Among MFAP3-related pathways are degradation of the extracellular matrix and elastic fiber formation. MFAP is a candidate gene for heritable diseases affecting microfibrils (2).

Long Name

Microfibrillar-Associated Protein 3

Entrez Gene IDs

4238 (Human); 216760 (Mouse); 287299 (Rat)

Alternate Names

DKFZp586F0219; MFAP3; microfibril-associated glycoprotein 3; microfibrillar-associated protein 3