Human mGluR8 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB5277U Datasheet / COA / SDS

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FAB5277U-100UG

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Human mGluR8 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human mGluR8 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human mGluR1, 2, 3, 4, 5, or 7 is observed.

Source

Monoclonal Mouse IgG2b Clone # 476410

Purification

Protein A or G purified

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human mGluR8
Gln34-Ser514 (predicted)
Accession # O00222

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: mGluR8

mGluR8 is a Group III metabotropic glutamate receptor. These 7-transmembrane glycoproteins are negatively coupled to adenylate cyclase and expressed presynaptically throughout the brain. mGluR8 shows pronounced expression in the dentate gyrus and CA3 regions of the hippocampus, and is thought to play a role in memory formation. Two splice forms, A and B, differ only in the C-terminal 16 amino acids (aa 893‑909), while splice form C diverges at aa 454 and is truncated prior to the first transmembrane segment. Within the N-terminal extracellular region used as an immunogen (aa 34‑514), human, mouse and rat mGluR8 share 98%‑99% aa identity.

Long Name

Metabotropic Glutamate Receptor 8

Entrez Gene IDs

2918 (Human); 14823 (Mouse); 60590 (Rat)

Alternate Names

FLJ41058; glutamate metabotropic receptor 8; glutamate receptor, metabotropic 8; GPRC1H; GPRC1HMGLUR8GLUR8; GRM8; metabotropic glutamate receptor 8; MGC126724; mGlu8; mGluR8