Human MKP-1 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB7168V Datasheet / COA / SDS

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FAB7168V-100UG

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Human MKP-1 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human MKP-1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) MKP-2, rhMKP-3, or rhMKP-5 is observed.

Source

Monoclonal Rat IgG2a Clone # 408612

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human MKP-1
Met1-Cys367
Accession # P28562

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: MKP-1

MKP-1, also known as PTPN10, DUSP1, and CL100, is an approximately 45 kDa Ser/Thr protein phosphatase that dephosphorylates p38 MAPK and JNK. Acetylation of MKP-1 enhances this activity and limits the inflammation-induced signaling downstream of TLR proteins. Within aa 1-367, human MKP-1 shares 97% aa sequence identity with mouse and rat MKP-1.

Long Name

MAP Kinase Phosphatase 1

Entrez Gene IDs

1843 (Human); 19252 (Mouse); 114856 (Rat)

Alternate Names

CL100; CL100MAP kinase phosphatase 1; dual specificity phosphatase 1; Dual specificity protein phosphatase hVH1; DUSP1; EC 3.1.3.16; EC 3.1.3.48; HVH1; Mitogen-activated protein kinase phosphatase 1; MKP1; MKP-1; MKP-1dual specificity protein phosphatase 1; Protein-tyrosine phosphatase CL100; PTPN10; PTPN10serine/threonine specific protein phosphatase; VH1