Human Nurr1/NGFI-B beta/NR4A2 MAb (Clone N1404)

Name: Human Nurr1/NGFI-B beta/NR4A2 MAb (Clone N1404)
Brand: R&D Systems
SKU: PP-N1404-00
Rating: 5 (1 reviews)

Catalog #: PP-N1404-00
2 Citations 1 Review Datasheet / COA / SDS

Newer Version Available: PP-N1404-0C

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Discontinued Product

PP-N1404-00 has been discontinued and is replaced by PP-N1404-0C.

All Nurr1/NGFI-B beta/NR4A2 Antibodies

Product Details

Citations (2)

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Reviews (1)

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Nurr1/NGFI-B beta/NR4A2 MAb (Clone N1404) Summary

Species Reactivity

Human

Source

Monoclonal Mouse IgG2a Clone # N1404

Formulation

A liquid formulation in physiologic saline with 0.1% NaN₃.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

Please refer to the PDF datasheet for specifications.

Immunohistochemistry

5-15 µg/mL

Perfusion fixed paraffin-embedded sections of rat cerebral nerve cells

Immunoprecipitation

Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Nurr1/NGFI-B beta/NR4A2

Nurr1 belongs to the nerve growth factor-induced clone B subfamily of nuclear receptor superfamily and is designated NR4A2 in the Unified Nomenclature System for NRs. Nurr1 can function as a ligand-independent transcription factor. Nurr1 also heterodimerizes with retinoid X receptors (RXRs) to function as ligand-regulated transcription factor. Nurr 1 is important for specification of dopaminergic neurons that degenerate in Parkinsons disease. Human and mouse Nurr1 share 99% amino acid sequence homology.

Long Name

Nur-related Factor 1/Nerve Growth Factor Induced B beta/Nuclear Receptor Subfamily 4, Group A, 2

Entrez Gene IDs

4929 (Human); 18227 (Mouse)

Alternate Names

human homolog of; NGFI-B beta; NOT; NR4A2; nuclear receptor subfamily 4, group A, member 2; Nurr1; orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; T-cell nuclear receptor NOT; TINUR; transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human Nurr1/NGFI-B beta/NR4A2 MAb (Clone N1404)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations
Authors: Kojima, R;Paslawski, W;Lyu, G;Arenas, E;Zhang, X;Svenningsson, P;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Immunocytochemistry
Expression of the nerve growth factor-induced gene B-beta in the developing rat brain and retina.
Authors: Li Y, Ohashi R, Naito M
Arch. Histol. Cytol., 2009-03-01;72(1):23-34.
Species: Human, Rat
Sample Types: Cell Lysates, Whole Tissue
Applications: IHC-P, Western Blot