Human/Rat GR/NR3C1 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB10144V Datasheet / COA / SDS

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FAB10144V-100UG

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Human/Rat GR/NR3C1 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human, Rat

Specificity

Detects human GR/NR3C1 in direct ELISAs. Detects human and rat GR/NR3C1 in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 1006903

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human GR/NR3C1
Val271-Lys777
Accession # P04150

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: GR/NR3C1

GR is a glucocorticoid receptor that is expressed in almost every cell in the body and regulates genes controlling development, metabolism and the immune response. The unbound receptor resides in the cytosol of the cell, but upon binding to glucocorticoids, it is translocated to the nucleus where it regulates gene transcription. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or acts to repress the expression of pro-inflammatory proteins in the cytosol. It is also involved in chromatin remodeling and plays a role in rapid mRNA degradation.

Long Name

Glucocorticoid Receptor

Entrez Gene IDs

2908 (Human)

Alternate Names

GCR; glucocorticoid receptor; GR; GRGCCR; GRLNuclear receptor subfamily 3 group C member 1; NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); nuclear receptor subfamily 3, group C, member 1