Human RUNX1/CBFA2 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB23991R Datasheet / COA / SDS

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FAB23991R-100UG

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All RUNX1/CBFA2 Antibodies

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Human RUNX1/CBFA2 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human RUNX1/CBFA2 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) RUNX2 or rhRUNX3 is observed.

Source

Monoclonal Mouse IgG2b Clone # 751926

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human RUNX1/CBFA2
Gly217-Tyr480
Accession # Q01196-8

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: RUNX1/CBFA2

RUNX1 (runt-related transcription factor 1), also known as CBFA2 (core-binding factor alpha 2) or AML1 (acute myelogenous leukemia 1), is a heterodimeric transcription factor that plays a role in normal hematopoiesis. Multiple splice variants exist. Defects in RUNX1 are associated with several types of leukemia.

Long Name

Runt-related Transcription Factor 1

Entrez Gene IDs

861 (Human); 12394 (Mouse); 50662 (Rat)

Alternate Names

Acute myeloid leukemia 1 protein; AML1; AML1acute myeloid leukemia 1; AML1-EVI-1; CBFA2; CBFA2acute myeloid leukemia 1 protein (oncogene AML-1), core-binding factor, alphasubunit10AMLCR1; Core-binding factor subunit alpha-2; EVI-1; PEBP2A2; runt domain, alpha subunit 2; runt-related transcription factor 1; RUNX1; SL3/AKV core-binding factor alpha B subunit