Human TAP2 Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB2432S Datasheet / COA / SDS

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FAB2432S-100UG

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Human TAP2 Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human TAP2 in direct ELISAs.

Source

Monoclonal Mouse IgG1 Clone # 998524

Purification

Protein A or G purified

Immunogen

Synthetic peptide containing human TAP2
Accession # Q03519

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: TAP2

TAP2 transports antigens from the cytoplasm to the endoplasmic reticulum, where they can bind to MHC class 1 molecules. It does this translocation by selecting peptides based on both their length and their sequence. The peptide selection occurs during the first step of the translocation process. Transmembrane segments of TAP form a pore in the membrane and the peptide binding site is formed by the cytosolic component of the pore. Inherited deficiency in the TAP transporter can lead to recurrent respiratory bacterial infections due to HLA class I deficiency (BLS1).

Long Name

Transporter 2, ATP Binding Cassette Subfamily B Member

Entrez Gene IDs

6891 (Human); 21355 (Mouse); 24812 (Rat)

Alternate Names

ABC18; ABCB3; ABCB3ABC18; antigen peptide transporter 2; APT2; ATP-binding cassette, sub-family B (MDR/TAP), member 3; D6S217E; MHC 2; Peptide transporter involved in antigen processing 2; Peptide transporter PSF2; Peptide transporter TAP2; PSF2; PSF2PSF-2; Really interesting new gene 11 protein; RING11; RING11ATP-binding cassette sub-family B member 3; TAP2; transporter 2, ABC (ATP binding cassette); transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); Y1