Tankyrase binding protein 1 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-89826

Novus Biologicals
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Tankyrase binding protein 1 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: DWTPDLGLRNMAPGAVCSPGESKELGVGQMDWGNNLGLRDLEVTCDPDSGGSQGLRGCGVGQMDWTQDLAPQNVELFGAPSEARE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Tankyrase binding protein 1 Antibody - BSA Free

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826] - Staining of human kidney, prostate, skeletal muscle and skin using Anti-TNKS1BP1 antibody NBP1-89826 (A) shows similar protein distribution across tissues to independent antibody NBP2-34041 (B).
Tankyrase binding protein 1 Antibody - BSA Free Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody - BSA Free [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody - BSA Free [NBP1-89826]

Analysis in human skin and skeletal muscle tissues using Anti-TNKS1BP1 antibody. Corresponding TNKS1BP1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826] - Staining of human skin shows high expression.
Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826] - Staining of human skeletal muscle shows low expression as expected.
Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826] - Staining of human prostate.
Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826]

Immunohistochemistry-Paraffin: Tankyrase binding protein 1 Antibody [NBP1-89826] - Staining of human kidney.

Applications for Tankyrase binding protein 1 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Tankyrase binding protein 1

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Alternate Names

KIAA1741TAB182FLJ45975,182 kDa tankyrase-1-binding protein, tankyrase 1 binding protein 1, 182kDa, tankyrase 1-binding protein of 182 kDa

Gene Symbol

TNKS1BP1

Additional Tankyrase binding protein 1 Products

Product Documents for Tankyrase binding protein 1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Tankyrase binding protein 1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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