Thyroid Peroxidase Antibody

Name: Thyroid Peroxidase Antibody
Brand: Novus Biologicals
SKU: NBP1-97765
Price: 399 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-97765

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

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Product Specifications

Immunogen

Peptide with sequence C-TRHVIQVSNEVVTDD corresponding to internal region according to NP_000538.3, NP_783650.1, NP_783652.1, NP_783653.1.

Specificity

This antibody is expected to recognize reported isoforms a (NP_000538.3) and e (NP_783653.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Thyroid Peroxidase Antibody

Western Blot: Thyroid Peroxidase Antibody [NBP1-97765]

Western Blot: Thyroid Peroxidase Antibody [NBP1-97765] - (0.3ug/ml) staining of Human Thyroid Gland lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-97765]

Immunohistochemistry-Paraffin: Thyroid Peroxidase Antibody [NBP1-97765] - Staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for Thyroid Peroxidase Antibody

Application

Recommended Usage

Immunohistochemistry

5 - 10 ug/ml

Peptide ELISA

Detection limit 1:16000

Western Blot

0.3 - 1 ug/ml

Application Notes

WB: Approx. 110 kDa band observed in human thyroid gland lysates (calculated MW of 103 kDa band according to NP_000538.3). IHC-P: Human thyroid gland shows textured staining in the cytoplasm of epithelial cells.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Thyroid Peroxidase

Thyroid Peroxidase encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined. [provided by RefSeq]

Alternate Names

EC 1.11.1, MSA, TDH2A, thyroid microsomal antigen, thyroid peroxidase, thyroperoxidase, TPXEC 1.11.1.8

Entrez Gene IDs

7173 (Human)

Gene Symbol

TPO

UniProt

NP_000538.3 (Human)

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Product Specific Notices for Thyroid Peroxidase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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