TNIP3 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-77365

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all TNIP3 Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ABIN3. The immunogen is located within the last 50 amino acids of ABIN3.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TNIP3 Antibody - BSA Free

Western Blot: TNIP3 AntibodyBSA Free [NBP1-77365]

Western Blot: TNIP3 AntibodyBSA Free [NBP1-77365]

Western Blot: TNIP3 Antibody [NBP1-77365] - Human spleen tissue lysate with TNIP3 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
TNIP3 Antibody - BSA Free

Immunohistochemistry: TNIP3 Antibody - BSA Free [NBP1-77365] -

Immunohistochemistry: TNIP3 Antibody - BSA Free [NBP1-77365] - Immunohistochemistry of TNIP3 in mouse spleen tissue with TNIP3 antibody at 5 ug/mL.

Applications for TNIP3 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TNIP3

The nuclear factor NF-kappaB plays key roles in development and immunity. ABIN3 (A20-binding inhibitor of NF-kappaB activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a novel negative feedback regulator of LPS-induced NF-kappaB activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kappaB activation in response to TNF and LPS. ABIN3 is highly expressed in brain, thymus, lymph node, lung and fetal liver, with low expression in kidney, bone marrow. Through its interaction with A20, ABIN3 interferes with TRAF2-mediated transactivation signals and NF-kappaB inhibition is mediated by the ABIN-homology domain 2. ABIN3 has been found to be induced by Listeria infection and can be slightly downregulated by dexamethasone. Enhanced expression of ABIN3 in monocytes is associated with sepsis. Thus, ABIN3 is an IL-10-induced gene product capable of attenuating NF-kappaB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions. At least four isoforms of ABIN3 are known to exist.

Alternate Names

A20, A20-binding inhibitor of NF-kappa-B activation 3, ABIN3, ABIN-3ABIN-3 beta, FLJ21162, LINDListeria induced, Listeria-induced gene protein, TNFAIP3 interacting protein 3, TNFAIP3-interacting protein 3, TNFAIP3-interacting protein 3 beta, TNIP3 beta

Gene Symbol

TNIP3

UniProt

NP_079149 (Human)

Additional TNIP3 Products

Product Documents for TNIP3 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for TNIP3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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