Klotho: Products

The Klotho proteins, Klotho and Klotho beta (beta KL), are type I transmembrane glycoproteins with extracellular regions that contain two beta-glycosidase-like repeats.

Klotho beta, a divergent structural member of the glycosidase I superfamily, is primarily expressed in the liver and pancreas, with lower expression in adipose tissue. Klotho beta mediates the interaction of FGF-15 (human FGF-19) with FGF Receptor 4 in the liver, which negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes. Klotho beta is also a cofactor for the interaction of FGF-21 with FGF Receptor 1c in adipocytes. The expression pattern of Klotho beta suggests it may play a role in lipid metabolism.

"Klotho" has 10 results in Products.
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Mouse Klotho Antibody 

Recombinant Human Klotho His-tag Protein, CF 

Mucin Stalk Chimera
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Klotho-derived peptide 1 

TGF-β receptor 2 (TβR2) binding peptide; disrupts the TGF-β/TβR2 interaction

Klotho-derived peptide 6 

Wnt/β-catenin signaling inhibitor
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