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12 results for "c-Abl Small Molecules and Peptides" in 产品

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c-Abl Small Molecules and Peptides

c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; ...

Dasatinib

Catalog #: 6793

Citations (40)

Product Documents

Highly potent pan-Src/Bcr-Abl inhibitor

Alternate Names:	BMS-354825
Chemical Name:	N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
Purity:	≥98%

Imatinib mesylate

Catalog #: 5906

Citations (14)

Product Documents

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

Alternate Names:	Gleevec,CGP 57148B
Chemical Name:	4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate
Purity:	≥98%

Bosutinib

Catalog #: 4361

Citations (16)

Product Documents

Dual Src-Abl inhibitor; antiproliferative

Alternate Names:	SKI-606
Chemical Name:	4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
Purity:	≥98%

PP 1

Catalog #: 1397

Citations (15)

Product Documents

Potent, selective Src family kinase inhibitor

Chemical Name:	1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥98%

1-Naphthyl PP1

Catalog #: 3063

Citations (15)

Product Documents

Src family kinase inhibitor; also inhibits c-Abl

Alternate Names:	1-NA-PP 1
Chemical Name:	1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥98%

AP 24534

Catalog #: 4274

Citations (4)

Product Documents

Potent multi-kinase and pan-Bcr-Abl inhibitor

Alternate Names:	Ponatinib
Chemical Name:	3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide
Purity:	≥98%

PPY A

Catalog #: 4730

Citations (4)

Product Documents

Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

Chemical Name:	5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide
Purity:	≥98%

GNF 5

Catalog #: 4908

Product Documents

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

Chemical Name:	N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
Purity:	≥98%

AEE 788

Catalog #: 5318

(2)

Citations (4)

Product Documents

Potent EGFR and VEGFR inhibitor

Chemical Name:	6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity:	≥98%

GNF 7

Catalog #: 5607

Citations (1)

Product Documents

Ras signaling inhibitor; inhibits Ack1 and GCK

Chemical Name:	N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Purity:	≥98%

Saracatinib

Catalog #: 7189

(1)

Citations (8)

Product Documents

Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable

Alternate Names:	AZD 0530
Chemical Name:	N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
Purity:	≥98%

GMB 475

Catalog #: 7265

Product Documents

BCR-ABL1 kinase PROTAC® Degrader

Chemical Name:	(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98%

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