c-Abl Products

Alternate Names:	BMS-354825
Chemical Name:	N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
Purity:	≥98%

Imatinib mesylate

Catalog #: 5906

Citations (14)

Product Documents

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

Alternate Names:	Gleevec,CGP 57148B
Chemical Name:	4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate
Purity:	≥98%

c-Abl Antibody (8E9)

Catalog #: NBP2-49695

(1)

Product Documents

Reactivity:	Human, Mouse
Details:	Mouse IgG₁ Monoclonal Clone #8E9
Applications:	IHC, WB, ICC/IF, IP

Bosutinib

Catalog #: 4361

Citations (16)

Product Documents

Dual Src-Abl inhibitor; antiproliferative

Alternate Names:	SKI-606
Chemical Name:	4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
Purity:	≥98%

c-Abl Antibody

Catalog #: NBP2-15631

Product Documents

Reactivity:	Human
Details:	Rabbit IgG Polyclonal
Applications:	IHC, WB, ICC/IF

c-Abl [p Tyr245] Antibody

Catalog #: NBP3-13326

Product Documents

Reactivity:	Human, Mouse, Rat
Details:	Rabbit IgG Polyclonal
Applications:	WB

Recombinant Human c-Abl His-tag Protein, CF

Catalog #: 11091-AL

Product Documents

Reactivity:	Human
Source:	E. coli
Accession #:	P00519.4
Applications:	Enzyme Activity

c-Abl Antibody - BSA Free

Catalog #: NBP1-90289

Citations (1)

Product Documents

Reactivity:	Human
Details:	Rabbit IgG Polyclonal
Applications:	IHC, ICC/IF

PP 1

Catalog #: 1397

Citations (15)

Product Documents

Potent, selective Src family kinase inhibitor

Chemical Name:	1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥98%

1-Naphthyl PP1

Catalog #: 3063

Citations (15)

Product Documents

Src family kinase inhibitor; also inhibits c-Abl

Alternate Names:	1-NA-PP 1
Chemical Name:	1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity:	≥98%

AP 24534

Catalog #: 4274

Citations (4)

Product Documents

Potent multi-kinase and pan-Bcr-Abl inhibitor

Alternate Names:	Ponatinib
Chemical Name:	3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide
Purity:	≥98%

PPY A

Catalog #: 4730

Citations (4)

Product Documents

Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

Chemical Name:	5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide
Purity:	≥98%

GNF 5

Catalog #: 4908

Product Documents

Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

Chemical Name:	N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
Purity:	≥98%

AEE 788

Catalog #: 5318

(2)

Citations (4)

Product Documents

Potent EGFR and VEGFR inhibitor

Chemical Name:	6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity:	≥98%

GNF 7

Catalog #: 5607

Citations (1)

Product Documents

Ras signaling inhibitor; inhibits Ack1 and GCK

Chemical Name:	N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Purity:	≥98%

Saracatinib

Catalog #: 7189

(1)

Citations (8)

Product Documents

Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable

Alternate Names:	AZD 0530
Chemical Name:	N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
Purity:	≥98%

GMB 475

Catalog #: 7265

Product Documents

BCR-ABL1 kinase PROTAC® Degrader

Chemical Name:	(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98%