9 results for "CDK Degraders" in 产品

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CDK Degraders

THAL SNS 032

Catalog #: 6532
Citations (5)
Product Documents

Potent and selective Cdk9 Degrader (PROTAC®)

Chemical Name: N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide
Purity: ≥98%
Application of THAL SNS 032 in MOLT-4 cells
(2)

BSJ-03-123

Catalog #: 6921
Citations (2)
Product Documents

Selective Cdk6 Degrader (PROTAC®)

Chemical Name: N-[2-[2-[2-[2-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity: ≥98%
Selective Cdk6 Degrader (PROTAC®)

BSJ-03-204

Catalog #: 6938
Citations (1)
Product Documents

Selective Cdk4/6 Degrader (PROTAC®

Chemical Name: N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity: ≥98%
Selective Cdk4/6 Degrader (PROTAC®)

JH-XI-10-02

Catalog #: 7304
Product Documents

CDK8 Degrader (PROTAC®)

Chemical Name: 15-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[(3β,5α,17β)-17-(7-isoquinolinyl)androstan-3-yl]-N-methyl-4,7,10,13-tetraoxapentadecanamide
Purity: ≥98%
CDK8 Degrader (PROTAC®)

BSJ-4-116

Catalog #: 7528
Citations (2)
Product Documents

Selective CDK12 PROTAC® Degrader

Chemical Name: N-[7-[(3R)-3-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity: ≥98%
Selective CDK12 PROTAC® Degrader

CPS2

Catalog #: 7800
Product Documents

Potent and selective CDK2 Degrader (PROTAC®)

Chemical Name: 4-[[5-Amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]ethyl]benzenesulfonamide
Purity: ≥98%
Potent and selective CDK2 degrader (PROTAC®)

LL-K9-3

Catalog #: 7813
Product Documents

Selective HyT-based degrader of the CDK9-cyclin T1 complex

Chemical Name: N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-1-[[2-[[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]acetyl]amino]ethyl]sulfonyl]-4-piperidinecarboxamide
Purity: ≥98%
Selective HyT-based degrader of the CDK9-cyclin T1 complex

HEMTAC 26

Catalog #: 7940
Product Documents

CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

Chemical Name: 4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-N-[[1-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-3-butyn-1-yl]-1H-1,2,3-triazol-4-yl]methyl]-1-piperazineacetamide
Purity: ≥95%
CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

MS 28

Catalog #: 8076
Product Documents

Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC®)

Chemical Name: (2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC&reg:)
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