14 results for "Compounds for HSC Proliferation and Renewal" in 产品
Compounds for HSC Proliferation and Renewal
Hematopoietic stem cells (HSCs) reside in the bone marrow and generate two progenitor cell lineages: myeloid and lymphoid cells. The myeloid cells include erythrocytes, platelets, neutrophils, basophils, eosinophils, monocytes/ macrophages, and dendritic cells. The lymphoid cells comprise natural killer cells, B and T lymphocytes.
Figure 1: Model of the hematopoietic hierarchy. HSCs have the potential to both self-renew and differentiate. Multipotent progenitors give rise to all ...
Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
| Chemical Name: | 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide |
| Purity: | ≥99% |
Highly selective GSK-3 inhibitor; acts as Wnt activator
| Alternate Names: | CHIR99021,CT99021 |
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥98% |
Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
| Alternate Names: | PGE2 |
| Chemical Name: | (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid |
| Purity: | ≥98% |
Selective inhibitor of p38 MAPK
| Alternate Names: | Adezmapimod |
| Chemical Name: | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine |
| Purity: | ≥98% |
Glutathione (GSH) precursor; neuroprotective
| Chemical Name: | (2R)-2-(Acetylamino)-3-mercaptopropanamide |
Potent GSK-3 inhibitor; also inhibits cdks
| Alternate Names: | 6BIO |
| Chemical Name: | (2'Z,3'E)-6-Bromoindirubin-3'-oxime |
| Purity: | ≥98% |
Potent aryl hydrocarbon receptor (AhR) antagonist
| Chemical Name: | 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide |
| Purity: | ≥98% |
PARP-1 inhibitor
| Chemical Name: | Pyridine-3-carboxamide |
| Purity: | ≥99% |
Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development
| Chemical Name: | (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid |
| Purity: | ≥95% |
Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment
| Chemical Name: | 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol |
| Purity: | ≥98% |
Dipeptidyl peptidase IV (DPP-IV) inhibitor
| Alternate Names: | Ile-Pro-Ile |
| Chemical Name: | L-Isoleucyl-L-prolyl-L-isoleucine |
| Purity: | ≥98% |
BET bromodomain inhibitor; arrests cell cycle at G1 phase
| Alternate Names: | TEN 010 |
| Chemical Name: | (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Purity: | ≥98% |
Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO
| Chemical Name: | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| Purity: | ≥97% |
Potent integrin inhibitor (αvβ3/αvβ6); also improves stem cell attachment in 3D cell culture scaffolds
| Purity: | ≥95% |
