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Lck Small Molecules and Peptides

Lck (p56lck) is a member of the Src family of non-receptor tyrosine kinases. It was identified as a gene rearranged and over-expressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. Lck behaves as a proto-oncogene and can lead to cell transformation upon activation. A number of human cancer cell lines show over-expression of Lck, pointing to a possible role for this kinase in the initiation and maintenance of the transformed state in human cancers.

PP 2

Catalog #: 1407
(1)
Citations (130)
Product Documents

Potent, selective Src family kinase inhibitor

Chemical Name: 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98%
Potent, selective Src family kinase inhibitor

Dasatinib

Catalog #: 6793
Citations (40)
Product Documents

Highly potent pan-Src/Bcr-Abl inhibitor

Alternate Names: BMS-354825
Chemical Name: N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide
Purity: ≥98%
Highly potent pan-Src/Bcr-Abl inhibitor

Src I1

Catalog #: 3642
Citations (8)
Product Documents

Dual site Src kinase inhibitor

Chemical Name: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
Purity: ≥98%
Dual site Src kinase inhibitor

WH-4-023

Catalog #: 5413
Citations (17)
Product Documents

Potent and selective Lck and Src inhibitor; also inhibits SIK

Alternate Names: KIN112
Chemical Name: 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
Purity: ≥98%
Potent and selective Lck and Src inhibitor; also inhibits SIK

TC-S 7003

Catalog #: 3567
Citations (1)
Product Documents

Potent Lck inhibitor

Chemical Name: 6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one
Purity: ≥98%
Potent Lck inhibitor

SU 6656

Catalog #: 6475
Citations (29)
Product Documents

Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable

Chemical Name: 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide
Purity: ≥95%
Potent ATP-competitive Src family kinase inhibitor; also AMPK inhibitor; cell permeable

Saracatinib

Catalog #: 7189
(1)
Citations (8)
Product Documents

Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable

Alternate Names: AZD 0530
Chemical Name: N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
Purity: ≥98%
Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable

SJ 11646

Catalog #: 7721
Product Documents

Potent and selective LCK Degrader (PROTAC®)

Chemical Name: N-(2-Chloro-6-methylphenyl)-2-((6-(4-(3-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)propyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
Purity: ≥98%
Potent and selective LCK Degrader (PROTAC®)
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