10Z-Hymenialdisine

Catalog # Availability Size / Price Qty
1532/500U
Cat.No. 1532 - 10Z-Hymenialdisine | C11H10BrN5O2 | CAS No. 82005-12-7
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Description: Pan kinase inhibitor; potently inhibits MEK1
Alternative Names: SK&F 108752

Chemical Name: (4Z)-4-(2-Amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one

Purity: ≥97%

Product Details
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Biological Activity

Pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively.) Inhibits NF-κB activation and blocks IL-8 production in U937 cells (IC50 values are 1-2 and 0.34-0.48 μM respectively).

Technical Data

M.Wt:
324.13
Formula:
C11H10BrN5O2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
82005-12-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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