Chemical Name: 1,2,3,4,5,6-Hexabromocyclohexane
Biological ActivityPotently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation.
Sandberg et al.
Citation for 1,2,3,4,5,6-Hexabromocyclohexane
The citations listed below are publications that use Tocris products. Selected citations for 1,2,3,4,5,6-Hexabromocyclohexane include:
1 Citation: Showing 1 - 1
Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
Authors: Rogers and Gahring
Genes Dev 2015;10:e0143319
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