Catalog Number: 2291
Alternate Names: NSC 7908
Chemical Name: 1,2,3,4,5,6-Hexabromocyclohexane
Biological Activity
Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.
Technical Data
  • M.Wt:
    557.54
  • Formula:
    C6H6Br6
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Storage:
    Store at RT
  • CAS No:
    1837-91-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation.
    Sandberg et al.
    J.Med.Chem., 2005;48:2526
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 1,2,3,4,5,6-Hexabromocyclohexane include:

1 Citations: Showing 1 - 1

  1. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    Genes Dev 2015;10:e0143319

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