Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ
M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ
M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ
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Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation.
Sandberg et al.
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