1,2,3,4,5,6-Hexabromocyclohexane
Chemical Name: 1,2,3,4,5,6-Hexabromocyclohexane
Biological Activity
Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of 1,2,3,4,5,6-Hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophosphorylation.
Sandberg et al.
J.Med.Chem., 2005;48:2526
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Citation for 1,2,3,4,5,6-Hexabromocyclohexane
The citations listed below are publications that use Tocris products. Selected citations for 1,2,3,4,5,6-Hexabromocyclohexane include:
1 Citation: Showing 1 - 1
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Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
Authors: Rogers and Gahring
Genes Dev 2015;10:e0143319
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