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1,2,3,4,5,6-Hexabromocyclohexane

2291 1 Citation Datasheet / COA / SDS

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1,2,3,4,5,6-Hexabromocyclohexane | CAS No. 1837-91-8 | JAK Kinase Inhibitors
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Description: Inhibits JAK2 autophosphorylation
Alternative Names: NSC 7908

Chemical Name: 1,2,3,4,5,6-Hexabromocyclohexane

Product Details
Citations (1)
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Biological Activity

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.

Technical Data

M.Wt:
557.54
Formula:
C6H6Br6
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Storage:
Store at RT
CAS No:
1837-91-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for 1,2,3,4,5,6-Hexabromocyclohexane

The citations listed below are publications that use Tocris products. Selected citations for 1,2,3,4,5,6-Hexabromocyclohexane include:

1 Citation: Showing 1 - 1

  1. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    Genes Dev  2015;10:e0143319

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