Discontinued Product

2291 has been discontinued.
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1,2,3,4,5,6-Hexabromocyclohexane | CAS No. 1837-91-8 | JAK Kinase Inhibitors
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Description: Inhibits JAK2 autophosphorylation
Alternative Names: NSC 7908

Chemical Name: 1,2,3,4,5,6-Hexabromocyclohexane

Product Details
Citations (1)

Biological Activity

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM.

Technical Data

Soluble to 10 mM in DMSO with gentle warming
Store at RT

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Citation for 1,2,3,4,5,6-Hexabromocyclohexane

The citations listed below are publications that use Tocris products. Selected citations for 1,2,3,4,5,6-Hexabromocyclohexane include:

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