A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3
) receptor antagonist (IC50
= 42 μ
M). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μ
M) and inhibits it at higher concentrations (up to 50 μ
M). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
STIM and Orai: the long-awaited constituents of store-operated calcium entry.
Varnai et al.
Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB).
Bai et al.
2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.
Maruyama et al.
Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltafe-dependent effect.
Xu et al.
Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB).
Togashi et al.
The citations listed below are publications that use Tocris products. Selected citations for 2-APB include:
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