2-APB

  ( 34 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1224
Chemical Name:2-Aminoethoxydiphenylborane
Product Details
Citations (34)
Reviews
Biological Activity
A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.
Technical Data
  • M.Wt:
    225.1
  • Formula:
    C14H16BNO
  • Solubility:
    Soluble to 10 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    524-95-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 2-APB include:

34 Citations: Showing 1 - 10
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  1. Connexin 32-mediated cell-cell communication is essential for hepatic differentiation from humanembryonic stem cells
    Authors: Qin Et al.
    Scientific Reports  2016;6:37388
  2. Activation of the neurokinin 3 receptor promotes filopodia growth and sprouting in rat embryonic hypothalamic cells.
    Authors: Flynn Et al.
    Carcinogenesis  2015;75:44896
  3. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
    Authors: Baron Et al.
    Dev Neurobiol  2015;6:e1629
  4. Pathophysiological significance of the two-pore domain K(+) channel K2P5.1 in splenic CD4(+)CD25(-) T cell subset from a chemically-induced murine inflammatory bowel disease model.
    Authors: Nakakura Et al.
    Cell Death Dis  2015;6:299
  5. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci  2015;35:3016
  6. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    Biomed Res Int  2015;10:e0125974
  7. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
    Authors: Fransen Et al.
    PLoS One  2015;10:e0121634
  8. Both neurons and astrocytes exhibited tetrodotoxin-resistant metabotropic glutamate receptor-dependent spontaneous slow Ca2+ oscillations in striatum.
    Authors: Tamura Et al.
    PLoS One  2014;9:e85351
  9. Capture of microtubule plus-ends at the actin cortex promotes axophilic neuronal migration by enhancing microtubule tension in the leading process.
    Authors: Hutchins and Wray
    J Biol Chem  2014;8:400
  10. Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs.
    Authors: Hendron Et al.
    Cell Calcium  2014;56:482
  11. Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
    Authors: Grimes Et al.
    Elife  2014;3:e03892
  12. Activation of a TRP-like channel and intracellular Ca2+ dynamics during phospholipase-C-mediated cell death.
    Authors: Gon&ccedil;alves Et al.
    J Cell Sci  2014;127:3817
  13. Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
    Authors: Varadarajan Et al.
    PLoS One  2013;8:e56603
  14. Antagonism of neuronal prostaglandin E(2) receptor subtype 1 mitigates amyloid β neurotoxicity in vitro.
    Authors: Li Et al.
    Biochem Pharmacol  2013;8:87
  15. AMP-activated protein kinase as regulator of P2Y(6) receptor-induced insulin secretion in mouse pancreatic β-cells.
    Authors: Balasubramanian Et al.
    Hypertension  2013;85:991
  16. Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
    Authors: Chang Et al.
    Front Cell Neurosci  2013;34:1096
  17. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    J Pharmacol Exp Ther  2013;33:11361
  18. In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium.
    Authors: Aihara Et al.
    PLoS One  2013;288:33585
  19. SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes.
    Authors: Huang Et al.
    Korean J Physiol Pharmacol  2012;7:e49954
  20. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  21. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia.
    Authors: Begum Et al.
    J Neurochem  2012;120:622
  22. Regulation of Substantia Nigra Pars Reticulata GABAergic Neuron Activity by H?O? via Flufenamic Acid-Sensitive Channels and K(ATP) Channels.
    Authors: Lee Et al.
    Front Syst Neurosci  2011;5:14
  23. Calcium-sensing receptor modulates extracellular Ca(2+) entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells.
    Authors: Chow Et al.
    PLoS One  2011;301:C461
  24. The amiloride-sensitive epithelial Na+ channel PPK28 is essential for drosophila gustatory water reception.
    Authors: Chen Et al.
    J Neurosci  2010;30:6247
  25. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation.
    Authors: Kim Et al.
    Front Physiol  2010;19:783
  26. Caffeine and 2-Aminoethoxydiphenyl Borate (2-APB) Have Different Ability to Inhibit Intracellular Calcium Mobilization in Pancreatic Acinar Cell.
    Authors: Choi Et al.
    J Neuroimmune Pharmacol  2010;14:105
  27. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation.
    Authors: Clark Et al.
    J Neurosci  2009;29:11237
  28. P2Y receptors mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion.
    Authors: Dong Et al.
    Am J Physiol Gastrointest Liver Physiol  2009;296:G424
  29. Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels.
    Authors: Sribnick Et al.
    Brain Res  2009;1276:159
  30. Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway.
    Authors: Bagayogo and Dreyfus
    ASN Neuro  2009;1
  31. Low concentrations of sphingosylphosphorylcholine enhance pulmonary artery vasoreactivity: the role of protein kinase C δ and Ca2+ entry.
    Authors: Snetkov Et al.
    Am J Physiol Cell Physiol  2008;51:239
  32. Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons.
    Authors: Kelm Et al.
    Stem Cells Dev  2007;323:356
  33. Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries.
    Authors: Villalba Et al.
    Am J Physiol Heart Circ Physiol  2007;292:H1157
  34. 2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels.
    Authors: Gu Et al.
    Am J Physiol Lung Cell Mol Physiol  2005;288:L932
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Other Experimental Details Put it into DMSO (100mM).

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