Catalog Number: 0782
Chemical Name: 2-Chloro-11-(4-methylpiperazino)dibenz(Z)[b,f]oxepin maleate
Biological Activity
Dopamine D2-like receptor antagonist that displays some selectivity for D4 receptors (Ki values are 0.54 and 2.5 nM for D4 and D2 receptors respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. L-745,870 suppresses the nighttime serotonin N-acetyltransferase activity in chick retina: in vivo evidence for agonist activity at D4-dopamine receptors.
    Zawilska et al.
    J.Neural Transm., 2003;110:219
  2. Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptane analogues of clozapine to dopamine and serotonin receptors.
    Phillips et al.
    J.Med.Chem., 1994;37:2686
  3. Binding of 5H-dibenzo[a,d]cycloheptane and dibenz[b,f]oxapin analogues of clozapine to dopamine and serotonin receptors.
    Phillips et al.
    J.Med.Chem., 1995;38:708

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