Catalog Number: 3015
Biological Activity
Potent and selective PAR2 receptor agonist (pD2 = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.
Technical Data
  • M.Wt:
    777.96
  • Formula:
    C36H63N11O8
  • Sequence:
    LIGRLX

    (Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    729589-58-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist.
    McGuire et al.
    J.Pharmacol.Exp.Ther., 2004;309:1124
  2. A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation.
    Alshurafa et al.
    BMC Pharmacol., 2004;4:12
  3. Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons.
    Olianas et al.
    Neuroscience, 2007;146:1289
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 2-Furoyl-LIGRLO-amide include:

2 Citations: Showing 1 - 2
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  1. Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis.
    Authors: Sales Et al.
    Am J Physiol Cell Physiol 2015;34:346
  2. Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.
    Authors: Pal Et al.
    J Biol Chem 2013;288:3265

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