Catalog Number: 0666
Chemical Name: 3-(4-Allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate
Biological Activity
A competitive 5-HT3 antagonist, almost 100 times more potent than tropisetron, but with widely differing activity in various tissues.
Technical Data
  • M.Wt:
    395.42
  • Formula:
    C16H17N5.C4H4O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
    201216-42-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes.
    Durk et al.
    Int.Immunol., 2005;17:599
  2. The pre-nervous serotonergic system of developing sea urchin embryos and larvae: pharmacologic and immunocytochemical evidence.
    Buznikov et al.
    Neurochem.Res., 2005;30:825
  3. Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives.
    Monge et al.
    J.Med.Chem., 1993;36:2745

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