Catalog Number: 0581
Chemical Name: 2-[(4-Phenylpiperazin-1-yl)methyl]-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one
Biological Activity
Very potent ligand for α1 sites (Ki for displacement of prazosin = 0.2 nM). Displays different binding properties for each α1 subtype (pKi values are 8.74, 9.44 and 9.57 for α1B, α1D and α1A adrenoceptors respectively). Also binds to 5-HT1A sites (Ki = 50 nM).
Technical Data
  • M.Wt:
    419.48
  • Formula:
    C23H25N5O3
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Storage:
    Store at RT
  • CAS No:
    133399-65-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective α1 adrenoceptor ligands.
    Russo et al.
    J.Med.Chem., 1991;34:1850
  2. New pyrimido[5,4-b]indoles as ligands for α1-adrenoceptor subtypes.
    Romeo et al.
    J.Med.Chem., 2003;46:2877

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