Very potent ligand for α1
for displacement of prazosin = 0.2 nM). Displays different binding properties for each α
1 subtype (pKi
values are 8.74, 9.44 and 9.57 for α1B
adrenoceptors respectively). Also binds to 5-HT1A
= 50 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective α1 adrenoceptor ligands.
Russo et al.
New pyrimido[5,4-b]indoles as ligands for α1-adrenoceptor subtypes.
Romeo et al.