Catalog Number: 4125
Chemical Name: (1R,5S)-1,2,3,4,5,6-Hexahydro-9-(3-pyridinyl)-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Biological Activity
High affinity α4β2 partial agonist (Ki values are 0.91, 119 and 1100 nM for α4β2, α3β4 and α7 receptors respectively). Shows little activity at α3β4 and α7 receptors. Exhibits antidepressant-like effects in mouse models of antidepressant efficacy.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cytisine-based nicotinic partial agonists as novel antidepressant compounds.
    Mineur et al.
    J.Pharmacol.Exp.Ther., 2009;329:377
  2. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.
    Papke et al.
    J.Pharmacol.Exp.Ther., 2010;333:501
  3. Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists.
    Papke et al.
    J.Pharmacol.Exp.Ther., 2011;337:1

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