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3',3'-cGAMP sodium salt

Catalog #: 5946 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5946/359U
3',3'-cGAMP sodium salt | CAS No. 2407516-83-8 | STING Agonists
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Description: STING agonist

Chemical Name: 3',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt

Purity: ≥98%

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Biological Activity

3',3'-cGAMP sodium salt is a STING agonist. Reduces B cell proliferation and induces apoptosis of malignant B cells in vitro. Suppresses 5TGM1 multiple myeloma xenograft growth in immunodeficient mice, and induces leukemic regression in Eμ-TCL1 mice.

This product is sold in units of 359μg, equivalent to 0.5μmol.

Technical Data

M.Wt:
718.37
Formula:
C20H22N10Na2O13P2
Solubility:
Soluble to 10 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2407516-83-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
  • This product is sold in units of 359μg, equivalent to 0.5μmol.

Background References

  1. Agonist-mediated activation of STING induces apoptosis in malignant B cells.
    Tang et al.
    Cancer Res., 2016;76:2137

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VersaClone cDNA Plasmids

Human STING/TMEM173 (NP_938023) VersaClone cDNA

RDC1468

Mouse STING/TMEM173 (NP_082537) VersaClone cDNA

RDC1469

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