STING agonist. Reduces B cell proliferation and induces apoptosis of malignant B cells in vitro
. Suppresses 5TGM1 multiple myeloma xenograft growth in immunodeficient mice, and induces leukemic regression in Eμ
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Agonist-mediated activation of STING induces apoptosis in malignant B cells.
Tang et al.
Cancer Res., 2016;76:2137