4-Acetyl-1,1-dimethylpiperazinium iodide
Discontinued Product
Biological Activity
4-Acetyl-1,1-dimethylpiperazinium iodide is a structural analog of acetylcholine that acts as a nicotinic agonist (Ki = 29.9 nM at α4β2). Upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors.
Spivak et al.
Mol.Pharmacol., 1988;36:177 -
Structural and electronic requirements for potent agonists at a nicotinic receptor.
Spivak et al.
Eur.J.Pharmacol., 1986;120:127 -
Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells.
Warpman et al.
J.Neurochem., 1998;70:2028
Product Datasheets
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