Catalog Number: 0352
Biological Activity
Structural analog of acetylcholine that acts as a nicotinic agonist (Ki = 29.9 nM at α4β2). Upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.
Technical Data
  • M.Wt:
    284.14
  • Formula:
    C8H17IN2O
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    75667-84-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells.
    Warpman et al.
    J.Neurochem., 1998;70:2028
  2. Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors.
    Spivak et al.
    Mol.Pharmacol., 1988;36:177
  3. Structural and electronic requirements for potent agonists at a nicotinic receptor.
    Spivak et al.
    Eur.J.Pharmacol., 1986;120:127

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