4-DAMP

Catalog # Availability Size / Price Qty
0482/50
4-DAMP | CAS No. 1952-15-4 | mAChR M3 Antagonists
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Description: Muscarinic M3 antagonist

Chemical Name: 1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide

Purity: ≥99%

Product Details
Citations (16)
Supplemental Products
Reviews

Biological Activity

4-DAMP is an antagonist at the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors.

Technical Data

M.Wt:
451.33
Formula:
C21H26INO2
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
1952-15-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A further search for selective antagonists at M2- muscarinic receptors.
    Barlow and Shepherd
    Br.J.Pharmacol., 1986;89:837
  2. Direct labelling of rat M3-muscarinic receptors by [3H]4-DAMP.
    Michel et al.
    Eur.J.Pharmacol., 1989;166:459

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Citations for 4-DAMP

The citations listed below are publications that use Tocris products. Selected citations for 4-DAMP include:

16 Citations: Showing 1 - 10

  1. SOX2 regulates acinar cell development in the salivary gland.
    Authors: Emmerson Et al.
    Elife  2017;6
  2. Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine.
    Authors: Wallace Et al.
    Microvasc Res  2015;3
  3. Diadenosine tetraphosphate contributes to CB-induced tear secretion.
    Authors: Fonseca Et al.
    Purinergic Signal  2015;11:87
  4. M2 Muscarinic acetylcholine receptor modulates rat airway smooth muscle cell proliferation.
    Authors: Placeres-Uray Et al.
    World Allergy Organ J  2014;6:22
  5. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland.
    Authors: Nedvetsky Et al.
    Dev Cell  2014;30:449
  6. M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells.
    Authors: Pacini Et al.
    Cancer Biol Ther  2014;15:1489
  7. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
    Authors: Mans Et al.
    J Neurophysiol  2014;112:2388
  8. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.
    Authors: Jahchan Et al.
    Cancer Discov  2013;3:1364
  9. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation.
    Authors: Kajiya Et al.
    J Neurosci  2012;82:115
  10. Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration.
    Authors: Chen Et al.
    J Biol Chem  2012;287:5059

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