Chemical Name: N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide
Biological ActivityCombines high affinity for σ1 and moderate affinity for σ2 sites. Centrally active following systemic administration in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition.
Whittemore et al.
Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands
Bermack and Debonnel
Synthesis and characterisation of [125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new sigma receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor cells.
John et al.
Citations for 4-IBP
The citations listed below are publications that use Tocris products. Selected citations for 4-IBP include:
2 Citations: Showing 1 - 2
Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Authors: Rodríguez-Muñoz Et al.
Mol Brain 2018;11:51
Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands.
Authors: Amer Et al.
Br J Pharmacol 2013;168:1445
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