Catalog Number: 0748
Chemical Name: N-(N-Benzylpiperidin-4-yl)-4-iodobenzamide
Biological Activity
Combines high affinity for σ1 and moderate affinity for σ2 sites. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO and to 5 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands
    Bermack and Debonnel
    Br.J.Pharmacol., 2001;134:691
  2. Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition.
    Whittemore et al.
    J.Pharmacol.Exp.Ther., 1997;282:326
  3. Synthesis and characterisation of [125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new sigma receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor cells.
    John et al.
    J.Med.Chem., 1994;37:1737
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