Selective inhibitor of IRE1α
ribonuclease (RNase) activity (IC50
= 60 nM). Blocks substrate access to the active site of IRE1α
. Inactivates IRE1α
-mediated mRNA degradation. Displays no effect on the IRE1α
-related endoribonuclease RNase L.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.
Cross et al.