4μ8C

Catalog # Availability Size / Price Qty
4479/10
4479/50

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4μ8C | CAS No. 14003-96-4 | IRE1 Inhibitors
1 Image
Description: Inhibits IRE1α endoribonuclease activity

Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde

Purity: ≥98%

Product Details
Citations (10)
Reviews

Biological Activity

4μ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

Technical Data

M.Wt:
204.18
Formula:
C11H8O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
14003-96-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 4μ8C

The citations listed below are publications that use Tocris products. Selected citations for 4μ8C include:

10 Citations: Showing 1 - 10

  1. Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation.
    Authors: Lisa G M Et al.
    Cell Mol Life Sci  2022;79:231
  2. CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival.
    Authors: Li-ying Et al.
    Int J Mol Sci  2022;23
  3. The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor.
    Authors: Mart Et al.
    J Biol Chem  2021;296:100295
  4. Monounsaturated fatty acids protect against palmitate-induced lipoapoptosis in human umbilical vein endothelial cells.
    Authors: Yuren Et al.
    PLoS One  2020;14:e0226940
  5. Evaluation of Compound Activity in Primary Human Intestinal Organoids Using Gene Expression and Histology.
    Authors: Mihee M Et al.
    Curr Protoc Pharmacol  2019;85:e54
  6. Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR.
    Authors: Yahui Et al.
    Elife  2019;8
  7. Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.
    Authors: Benoit Et al.
    Cell  2019;177:1201-1216.e19
  8. Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.
    Authors: Judith A Et al.
    Sci Transl Med  2019;11
  9. TLR7-mediated activation of XBP1 correlates with the IFNα production in humans
    Authors: Beisel
    Cytokine  2017;94:55
  10. A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.
    Authors: Amin-Wetzel Et al.
    Cell  2017;171:1625

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