Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Biological ActivitySelective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.
Cross et al.
Citations for 4μ8C
The citations listed below are publications that use Tocris products. Selected citations for 4μ8C include:
2 Citations: Showing 1 - 2
TLR7-mediated activation of XBP1 correlates with the IFNα production in humans
A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.
Authors: Amin-Wetzel Et al.
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