Catalog Number: 4479
Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Biological Activity
Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.
Technical Data
  • M.Wt:
    204.18
  • Formula:
    C11H8O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    14003-96-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.
    Cross et al.
    Proc.Natl.Acad.Sci.USA, 2012;109:E869
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 4μ8C include:

1 Citations: Showing 1 - 1

  1. TLR7-mediated activation of XBP1 correlates with the IFNα production in humans
    Authors: Beisel
    Cytokine 2017;94:55

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