5-Oxo-ETE
Discontinued Product
Chemical Name: 5-Oxo-(6E,8Z,11Z,14Z)-6,8,11,14-eicosatetraenoic acid
Purity: ≥95%
Biological Activity
Potent oxoeicosanoid (OXE) receptor agonist (EC50 = 0.33 nM). Chemoattractant for both neutrophils and eosinophils and induces transendothelial migration of eosinophils.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Effects of phorbol myristate acetate on the synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid by human polymorphonuclear leukocytes.
Powell et al.
Biochemistry, 1994;33:3927 -
Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils.
Jones et al.
Mol.Pharmacol., 2003;63:471 -
Structural requirements for activation of the 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor: identification of a mead acid metabolite with potent agonist activity.
Patel et al.
J.Pharmacol.Exp.Ther., 2008;325:698
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