6-Hydroxydopamine hydrobromide

Catalog # Availability Size / Price Qty
2547/50
Cat.No. 2547 - 6-Hydroxydopamine hydrobromide | C8H11NO3.HBr | CAS No. 636-00-0
1 Image
Description: Selective catecholaminergic neurotoxin
Alternative Names: 6-OHDA

Chemical Name: 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide

Product Details
Citations (9)
Reviews (1)

Biological Activity

Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.

Technical Data

M.Wt:
250.09
Formula:
C8H11NO3.HBr
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
636-00-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 6-Hydroxydopamine hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for 6-Hydroxydopamine hydrobromide include:

9 Citations: Showing 1 - 9

  1. External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway.
    Authors: Fan
    Proc Natl Acad Sci U S A.  2018;115(29):E6880
  2. Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model.
    Authors: Sérriàre Et al.
    PLoS One  2015;2:61
  3. Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model.
    Authors: Ray Et al.
    Cell Death Dis  2014;5:e984
  4. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
    Authors: Reinhardt Et al.
    Neural Plast  2013;8:e59252
  5. ER stress inhibits neuronal death by promoting autophagy.
    Authors: Fouillet Et al.
    Front Med (Lausanne)  2012;8:915
  6. Use of PC12 cells and rat superior cervical ganglion sympathetic neurons as models for neuroprotective assays relevant to Parkinson's disease.
    Authors: Grau and Greene
    Methods Mol Biol  2012;846:201
  7. Suppression of bladder overactivity by adenosine A2A receptor antagonist in a rat model of Parkinson disease.
    Authors: Kitta Et al.
    J Urol  2012;187:1890
  8. Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
    Authors: Malagelada Et al.
    J Neurosci  2010;30:1166
  9. RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation.
    Authors: Malagelada Et al.
    J Neurosci  2008;28:14363

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Great neurotoxic effects in dopaminergic neurons
By Luiz Alexandre Magno on 07/03/2018
Species: Mouse

I used the 6-Hydroxydopamine (6-OHDA) to deplete dopaminergic cells from the mouse brain, which is largely used as an experimental model of Parkinson's Disease. The 6-OHDA was injected into the mouse striatum and 21 days later we observed that the dopaminergic neurons (positive for tyrosine hydroxylase immunofluorescence) were almost absent in the substantia nigra pars compacta (SNc) from the 6-OHDA injected hemisphere (on the left). As a control for analytical comparisons, we also injected PBS into the contralateral hemisphere (on the right). When this neurotoxin is injected into striatum, as in this case, there is only a slight depletion of dopaminergic neurons from the ventral tegmental area (the region located into the middle of the image). The animals injected with 6-OHDA display several motor dysfunctions and are used to study the pathology and therapies for Parkinsonian symptoms.

Reference

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