hh 6-Hydroxydopamine hydrobromide (CAS 636-00-0): R&D Systems
Catalog Number: 2547
Alternate Names: 6-OHDA
Chemical Name: 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide
Biological Activity
Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.
Technical Data
  • M.Wt:
    250.09
  • Formula:
    C8H11NO3.HBr
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
    636-00-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: evidence for selective degeneration of catecholamine neurons.
    Breese and Traylor
    J.Pharmacol.Exp.Ther., 1970;174:413
  2. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease.
    Soto-Otero et al.
    J.Neurochem., 2000;74:1605
  3. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway.
    Fujita et al.
    Brain Res., 2006;1113:10
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 6-Hydroxydopamine hydrobromide include:

6 Citations: Showing 1 - 6
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  1. Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model.
    Authors: Sérriàre Et al.
    PLoS One 2015;2:61
  2. Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
    Authors: Reinhardt Et al.
    Neural Plast 2013;8:e59252
  3. ER stress inhibits neuronal death by promoting autophagy.
    Authors: Fouillet Et al.
    Front Med (Lausanne) 2012;8:915
  4. Use of PC12 cells and rat superior cervical ganglion sympathetic neurons as models for neuroprotective assays relevant to Parkinson's disease.
    Authors: Grau and Greene
    Methods Mol Biol 2012;846:201
  5. Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease.
    Authors: Malagelada Et al.
    J Neurosci 2010;30:1166
  6. RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation.
    Authors: Malagelada Et al.
    J Neurosci 2008;28:14363

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