A 68930 hydrochloride (CAS 130465-39-3): R&D Systems
Catalog Number: 1534
Chemical Name: cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride
Biological Activity
Potent and selective D1-like dopamine receptor agonist (EC50 values are 2.1 and 3910 nM for D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    307.78
  • Formula:
    C16H17NO3.HCl
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    130465-39-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Psychopharmacological distinction between novel full-efficacy "D1-like" dopamine receptor agonists.
    Deveney and Waddingto
    Pharmacol.Biochem.Behav., 1997;58:551
  2. A68930: a potent and specific agonist for the D-1 dopamine receptor.
    Kebabian et al.
    Am.J.Hypertens., 1990;3:40S
  3. (1R,3S)-1-(Aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.
    Quaglia et al.
    J.Med.Chem., 1990;33:2948
Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 68930 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle.
    Authors: Mizuta Et al.
    PLoS One 2013;14:89
  2. Phosphorylation of mouse melanopsin by protein kinase A.
    Authors: Blasic Et al.
    Sci Rep 2012;7:e45387
  3. Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.
    Authors: Guha Et al.
    J Neurochem 2012;122:823

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