A 769662

Catalog # Availability Size / Price Qty
3336/10
3336/50
Cat.No. 3336 - A 769662 | C20H12N2O3S | CAS No. 844499-71-4
1 Image
Description: Potent AMPK activator

Chemical Name: 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

Purity: ≥98%

Product Details
Citations (20)
Supplemental Products
Reviews

Biological Activity

Potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 μM) that displays selectivity towards β1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC50 = 3.2 μM) and decreases plasma glucose and triglyceride levels in vivo. Also inhibits proliferation of mesenchymal stem cells, and impedes reprogramming of mouse embryonic fibroblasts to iPSCs. Activates autophagy.

Technical Data

M.Wt:
360.39
Formula:
C20H12N2O3S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
844499-71-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for A 769662

The citations listed below are publications that use Tocris products. Selected citations for A 769662 include:

20 Citations: Showing 1 - 10

  1. Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE.
    Authors: Mahapatra Et al.
    J Biol Chem  2017;292:64
  2. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.
    Authors: Dai Et al.
    Autophagy  2017;13:1435
  3. AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner.
    Authors: Vlachaki Walker Et al.
    Diabetes Obes.Metab.  2017;
  4. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells.
    Authors: Saric Et al.
    Arterioscler Thromb Vasc Biol  2016;27:321
  5. Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase.
    Authors: M?ller-Durovic Et al.
    J Immunol  2016;197:2891
  6. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro.
    Authors: Walter Et al.
    Neuropharmacology  2016;108:24
  7. Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids.
    Authors: Peart Et al.
    Oncotarget  2015;6:22424
  8. Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury.
    Authors: Hwang Et al.
    J Pharmacol Exp Ther  2015;38:843
  9. Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity.
    Authors: Kenney Et al.
    J Neurosci  2015;35:3034
  10. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells.
    Authors: Weikel Et al.
    Am J Physiol Cell Physiol  2015;308:C249
  11. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
    Authors: López-Cotarelo Et al.
    Mol Cell  2015;290:827
  12. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
    Authors: Mo Et al.
    Nat Cell Biol  2015;17:500
  13. Bidirectional regulation of P body formation mediated by eIF4F complex formation in sensory neurons.
    Authors: Melemedjian Et al.
    Neurosci Lett  2014;563:169
  14. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.
    Authors: Wu Et al.
    Arthritis Rheum  2013;49:1167
  15. AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization.
    Authors: Mack Et al.
    Autophagy  2012;8:1197
  16. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.
    Authors: Lo Et al.
    J Cell Biol  2012;199:1117
  17. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α.
    Authors: Terkeltaub Et al.
    Proc Natl Acad Sci U S A  2011;63:1928
  18. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
    Authors: Bumpus and Johnson
    J Biol Chem  2011;339:886
  19. AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300.
    Authors: Zhang Et al.
    Mol Cells  2011;31:2897
  20. Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury.
    Authors: Paiva Et al.
    Am J Physiol Heart Circ Physiol  2011;300:H2123

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for A 769662

There are currently no reviews for this product. Be the first to review A 769662 and earn rewards!

Have you used A 769662?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.