A 769662

  ( 18 citations )    
Product Datasheet
Catalog Number:3336
Chemical Name:6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
Product Details
Citations (18)
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Biological Activity
Potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 μM) that displays selectivity towards β1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC50 = 3.2 μM) and decreases plasma glucose and triglyceride levels in vivo. Also inhibits proliferation of mesenchymal stem cells, and impedes reprogramming of mouse embryonic fibroblasts to iPSCs. Activates autophagy.
Technical Data
  • M.Wt:
    360.39
  • Formula:
    C20H12N2O3S
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    844499-71-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 769662 include:

18 Citations: Showing 1 - 10
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  1. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK.
    Authors: Dai Et al.
    Autophagy  2017;13:1435
  2. AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner.
    Authors: Vlachaki Walker Et al.
    Diabetes Obes.Metab.  2017;
  3. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells.
    Authors: Saric Et al.
    Arterioscler Thromb Vasc Biol  2016;27:321
  4. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro.
    Authors: Walter Et al.
    Neuropharmacology  2016;108:24
  5. Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids.
    Authors: Peart Et al.
    Oncotarget  2015;6:22424
  6. Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury.
    Authors: Hwang Et al.
    J Pharmacol Exp Ther  2015;38:843
  7. Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity.
    Authors: Kenney Et al.
    J Neurosci  2015;35:3034
  8. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells.
    Authors: Weikel Et al.
    Am J Physiol Cell Physiol  2015;308:C249
  9. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells.
    Authors: López-Cotarelo Et al.
    Mol Cell  2015;290:827
  10. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
    Authors: Mo Et al.
    Nat Cell Biol  2015;17:500
  11. Bidirectional regulation of P body formation mediated by eIF4F complex formation in sensory neurons.
    Authors: Melemedjian Et al.
    Neurosci Lett  2014;563:169
  12. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.
    Authors: Wu Et al.
    Arthritis Rheum  2013;49:1167
  13. AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization.
    Authors: Mack Et al.
    Autophagy  2012;8:1197
  14. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.
    Authors: Lo Et al.
    J Cell Biol  2012;199:1117
  15. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α.
    Authors: Terkeltaub Et al.
    Proc Natl Acad Sci U S A  2011;63:1928
  16. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
    Authors: Bumpus and Johnson
    J Biol Chem  2011;339:886
  17. AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300.
    Authors: Zhang Et al.
    Mol Cells  2011;31:2897
  18. Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury.
    Authors: Paiva Et al.
    Am J Physiol Heart Circ Physiol  2011;300:H2123
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