A 803467

  ( 6 citations )    
Product Datasheet
Catalog Number:2976
Chemical Name:5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
Product Details
Citations (6)
Reviews
Biological Activity
Selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.
Technical Data
  • M.Wt:
    357.79
  • Formula:
    C19H16ClNO4
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    944261-79-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 803467 include:

6 Citations: Showing 1 - 6
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  1. CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain
    Authors: Wu Et al.
    Scientific Reports  2016;6:34836
  2. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.
    Authors: Mascanfroni Et al.
    Biol Open  2015;21:638
  3. Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery.
    Authors: Curtright Et al.
    PLoS One  2015;10:e0116766
  4. Functional upregulation of nav1.8 sodium channels on the membrane of dorsal root Ganglia neurons contributes to the development of cancer-induced bone pain.
    Authors: Liu Et al.
    PLoS One  2014;9:e114623
  5. Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels.
    Authors: Stone Et al.
    Nat Med  2013;543:177
  6. Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis.
    Authors: Schuelert and McDougall
    Arthritis Res Ther  2012;14:R5

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