A 803467

Catalog # Availability Size / Price Qty
2976/10
2976/50
Voltage-gated Sodium Channel Blockers Small Molecule
1 Image
Description: Selective NaV1.8 channel blocker

Chemical Name: 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide

Purity: ≥98%

Product Details
Citations (7)
Reviews

Biological Activity

Selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

Technical Data

M.Wt:
357.79
Formula:
C19H16ClNO4
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
944261-79-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Painful research: identification of a small-molecule inhibitor that selectively targets NaV1.8 sodium channels.
    Rush and Cummins
    Mol.Interv., 2007;7:192
  2. A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.
    McGaraughty et al.
    J.Pharmacol.Exp.Ther., 2008;324:1204
  3. Discovery and biological evaluation of 5-Aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
    Kort et al.
    J.Med.Chem., 2008;51:407
  4. A-803467, a potent and selective NaV1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
    Jarvis et al.
    Proc.Natl.Acad.Sci., 2007;104:8520

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Citations for A 803467

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