Selective blocker of NaV
1.8 channels (IC50
values are 8, 2450, 6740, 7340 and 7380 nM for hNaV
1.5 and hNaV
1.2 channels respectively). Shows no significant activity against TRPV1, P2X2/3
2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Painful research: identification of a small-molecule inhibitor that selectively targets NaV1.8 sodium channels.
Rush and Cummins
A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.
McGaraughty et al.
Discovery and biological evaluation of 5-Aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
Kort et al.
A-803467, a potent and selective NaV1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Jarvis et al.
The citations listed below are publications that use Tocris products. Selected citations for A 803467 include:
Showing Results 1 - 3 of 3