Catalog Number: 2976
Chemical Name: 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
Biological Activity
Selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively). Shows no significant activity against TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.
Technical Data
  • M.Wt:
    357.79
  • Formula:
    C19H16ClNO4
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    944261-79-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Painful research: identification of a small-molecule inhibitor that selectively targets NaV1.8 sodium channels.
    Rush and Cummins
    Mol.Interv., 2007;7:192
  2. A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats.
    McGaraughty et al.
    J.Pharmacol.Exp.Ther., 2008;324:1204
  3. Discovery and biological evaluation of 5-Aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
    Kort et al.
    J.Med.Chem., 2008;51:407
  4. A-803467, a potent and selective NaV1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
    Jarvis et al.
    Proc.Natl.Acad.Sci., 2007;104:8520
Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 803467 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. CXCL13/CXCR5 enhances sodium channel Nav1.8 current density via p38 MAP kinase in primary sensory neurons following inflammatory pain
    Authors: Wu Et al.
    Scientific Reports 2016;6:34836
  2. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.
    Authors: Mascanfroni Et al.
    Biol Open 2015;21:638
  3. Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery.
    Authors: Curtright Et al.
    PLoS One 2015;10:e0116766
  4. Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels.
    Authors: Stone Et al.
    Nat Med 2013;543:177

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