Catalog Number: 2133
Alternate Names: α-Bgtx, α-BuTX
Biological Activity
Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM and > 3 μM respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Disulfide bridge between 3 - 23, 16 - 44, 29 - 33, 48 - 59, 60 - 65)

  • Solubility:
    Soluble in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels.
    Zhang et al.
    Neuron, 1994;12:167
  2. Unmasking the functions of the chromaffin cell α7 nicotinic receptor by using short pulses of acetylcholine and selective blockers.
    Lopez et al.
    Proc.Natl.Acad.Sci.USA, 1998;95:14184

The citations listed below are publications that use Tocris products. Selected citations for α-Bungarotoxin include:

Showing Results 1 - 10 of 18

  1. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity.
    Authors: Miyamoto Et al.
    J Neurosci
  2. The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors.
    Authors: Chatzidaki Et al.
    PLoS One
  3. Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish.
    Authors: Singh Et al.
  4. Novel aspects of cholinergic regulation of colonic ion transport.
    Authors: Bader and Diener
    J Biol Chem
  5. Selective Gating of Neuronal Activity by Intrinsic Properties in Distinct Motor Rhythms.
    Authors: Li
  6. Cholinergic control of γ power in the midbrain spatial attention network.
    Authors: Bryant Et al.
    Proc Natl Acad Sci U S A
  7. Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.
    Authors: Gill-Thind Et al.
    J Biol Chem
  8. Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.
    Authors: Spurny Et al.
  9. Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption.
    Authors: Ślimak Et al.
    Front Hum Neurosci
  10. The α 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes.
    Authors: Macpherson Et al.
    J Neurosci
  11. Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
    Authors: Zhong Et al.
    Pharmacol Res Perspect
  12. Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the β2 nicotinic acetylcholine receptor.
    Authors: Némethova Et al.
    Inflamm Res
  13. Fast silencing reveals a lost role for reciprocal inhibition in locomotion.
    Authors: Moult Et al.
  14. Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity.
    Authors: Kamynina Et al.
    Int J Biochem Cell Biol
  15. CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation.
    Authors: Sala Et al.
    Br J Pharmacol
  16. CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression.
    Authors: Krais Et al.
  17. Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior.
    Authors: Demarque and Spitzer
  18. Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals.
    Authors: Sun Et al.
    Mol Cancer Ther
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