AA 2414
Chemical Name: 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid
Purity: ≥98%
Biological Activity
AA 2414 is a thromboxane A2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA2 mimetic in guinea pigs.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids.
Ashida et al.
Prostaglandins, 1989;38:91 -
Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414.
Kurokawa et al.
Biol.Pharm.Bull., 1994;17:383 -
Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers.
Cui et al.
Eur.J.Pharmacol., 2007;576:99
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Citation for AA 2414
The citations listed below are publications that use Tocris products. Selected citations for AA 2414 include:
1 Citation: Showing 1 - 1
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The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle.
Authors: Hennenberg Et al.
Am J Physiol Renal Physiol 2013;305:F1383
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