Catalog Number: 3025
Alternate Names: Seratrodast
Chemical Name: 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid
Biological Activity
Thromboxane A2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA2 mimetic in guinea pigs.
Technical Data
  • M.Wt:
    354.44
  • Formula:
    C22H26O4
  • Solubility:
    Soluble to 75 mM in 1.1eq. NaOH and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    112665-43-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids.
    Ashida et al.
    Prostaglandins, 1989;38:91
  2. Antagonism of the human thromboxane A2 receptor by an anti-asthmatic agent AA-2414.
    Kurokawa et al.
    Biol.Pharm.Bull., 1994;17:383
  3. Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers.
    Cui et al.
    Eur.J.Pharmacol., 2007;576:99

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