Abacavir hemisulfate
Chemical Name: (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hemisulfate
Purity: ≥99%
Biological Activity
Abacavir hemisulfate is a competitive reverse transcriptase inhibitor; inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity.
Daluge et al.
Antimicrob Agents Chemother., 1997;41:1082 -
Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor aba. (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group.
Harrigan et al.
J.Infect.Dis., 2000;181:912 -
N-terminal valine adduct from the anti-HIV drug aba. in rat haemoglobin as evidence for aba. metabolism to a reactive aldehyde in vivo.
Charneira et al.
Br.J.Pharmacol., 2012;167:1353
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