Chemical Name: (2Z,4E)-5-[(1S)-1-Hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl]-3-methyl-2,4-pentadienoic acid
Biological ActivityEndogenous lanthionine synthetase C-like 2 (LANCL2) ligand. Stimulates glucose uptake by myocytes and pre-adipocytes in vitro, and by brown adipose tissue in vivo. Acts as a pro-inflammatory modulator of innate immune system cells. Stimulates proliferation of human mesenchymal and hematopoietic stem cells. Also used to control Cas9 via a RNA polymerase-based biosensor.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A novel lanthionine synthetase C-Like 2-based therapeutic for inflammatory bowel disease.
Carbo et al.
G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2.
Fresia et al.
Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo.
Sturla et al.
Multidimensional control of Cas9 by evolved RNA polymerase-based biosensors.
Pu et al.
ACS Chem.Biol., 2018;13:431
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