Catalog Number: 2372
Chemical Name: 5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-amine dihydrochloride
Biological Activity
Potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.
Technical Data
  • M.Wt:
    536.26
  • Formula:
    C22H19N6OBr.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1188890-28-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I In vitro characterization and acute antinociceptive
    Jarvis et al.
    J.Pharmacol.Exp.Ther., 2000;295:1156
  2. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties II. In vivo characterization in the rat.
    Kowaluk et al.
    J.Pharmacol.Exp.Ther., 2000;295:1165
  3. Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.
    Lee et al.
    J.Med.Chem., 2001;44:2133
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ABT 702 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. Adenosine kinase regulation of cardiomyocyte hypertrophy.
    Authors: Fassett Et al.
    Am J Physiol Heart Circ Physiol 2011;300:H1722

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