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Description: Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

Purity: ≥95%

Product Details
Citations (5)

Biological Activity

Ac2-26 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory.

Technical Data


(Modifications: Ala-1 = N-terminal Ac)

Soluble to 1 mg/ml in PBS
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
    Leoni, Giovanna, Neumann, Philipp-, Kamaly, Nazila, Quiros, Miguel, Nishio, Hikaru, Jones, Hefin R, Sumagin, Ronen, Hilgarth, Roland S, Alam, Ashfaqul, Fredman, Gabriell, Argyris, Ioannis, Rijcken, Emile, Kusters, Dennis, Reutelingsperger, Chris, Perretti, Mauro, Parkos, Charles, Farokhzad, Omid C, Neish, Andrew S, Nusrat, Asma
    J Clin Invest, 2015;125(3):1215-27.
  2. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1.
    Lim et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:14535
  3. Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody.
    Perretti et al.
    J.Immunol., 1993;151:4306
  4. Annexin 1: an endogenous anti-inflammatory protein.
    Perretti and Gavins
    News Physiol.Sci., 2003;18:60

Product Datasheets

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