Catalog Number: 1845
Biological Activity
Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory.
Technical Data
  • M.Wt:
    3089.46
  • Formula:
    C141H210N32O44S
  • Sequence:
    AMVSEFLKQAWFIENEEQEYVQTVK

    (Modifications: Ala-1 = N-terminal Ac)

  • Solubility:
    Soluble to 1 mg/ml in PBS
  • Storage:
    Desiccate at -20°C
  • CAS No:
    151988-33-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from The William Harvey Research Institute
Background References
  1. Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody.
    Perretti et al.
    J.Immunol., 1993;151:4306
  2. Annexin 1: an endogenous anti-inflammatory protein.
    Perretti and Gavins
    News Physiol.Sci., 2003;18:60
  3. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1.
    Lim et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:14535
  4. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
    Leoni et al.
    J.Clin.Invest., 2015;125:1215
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ac2-26 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Human neutrophil formyl peptide receptor phosphorylation and the mucosal inflammatory response.
    Authors: Leoni Et al.
    Hum Mol Genet 2015;97:87
  2. Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice.
    Authors: Fredman Et al.
    Sci Transl Med 2015;7:275ra20
  3. Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils.
    Authors: Dalli Et al.
    Front Pharmacol 2012;3:28
  4. Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.
    Authors: Brancaleone Et al.
    J Immunol 2011;186:4905

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