Ac2-26

Tocris Bioscience | Catalog # 1845

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
Tocris Bioscience

Key Product Details

Description

Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation
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Product Description

Ac2-26 is an annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Ac2-26 reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic injury in mice in vivo. Anti-inflammatory. Ac2-26 inhibits the proliferation of human larynx epidermoid carcinoma Hep-2 cells in vitro. Ac2-26 decreases proliferation and increases mobility of cervical cancer cells.

Negative control also available.

Product Specifications for Ac2-26

Molecular Weight

3089.46

Formula

C141H210N32O44S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

151988-33-9

PubChem ID

16138723

InChI Key

ODWGEWZOPBDSHW-ISLQBSBZSA-N

SMILES

CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(C)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in PBS

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 46 publications citing the usage of this product.

Product Documents for Ac2-26

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ac2-26

For research use only

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