Catalog Number: 0258
Chemical Name: 1-Aminocyclobutane-1-carboxylic acid
Biological Activity
NMDA receptor partial agonist, acting at the glycine site of NR1.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 1-Aminocyclobutane-1-carboxylic acid (ACBC): a specific antagonist of the NMDA receptor coupled glycine receptor.
    Hood et al.
    Eur.J.Pharmacol., 1989;161:281
  2. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.
    Inanobe et al.
    Neuron, 2005;47:71
  3. Neuropharmacological characterization of 1-aminocyclopropane-1-carboxylate and 1-aminocyclobutane-1-carboxylate, ligands of the N-methyl-D-aspartate-associated glycine receptor.
    Rao et al.
    Neuropharmacology, 1990;29:305

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