ACEA

  ( 30 citations )    
Product Datasheet
Catalog Number:1319
Alternate Names:Arachidonyl-2'-chloroethylamide
Chemical Name:N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Product Details
Citations (30)
Supplemental Products
Reviews
Biological Activity
Potent and highly selective CB1 receptor agonist (Ki = 1.4 nM). Displays >1400-fold selectivity over CB2 receptors. Active in vivo.
Technical Data
  • M.Wt:
    365.99
  • Formula:
    C22H36ClNO
  • Solubility:
    Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
  • Storage:
    Store at -20°C
  • CAS No:
    220556-69-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ACEA include:

30 Citations: Showing 1 - 10
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  1. Bidirectional allosteric interactions between cannabinoid receptor 1 (CB1) and dopaminereceptor 2 long (D2L) heterotetramers.
    Authors: Bagher
    Eur J Pharmacol  2017;813:66
  2. A long-term treatment with arachidonyl-2''chloroethylamide combined with valproate increases neurogenesis in a mouse pilocarpine model of epilepsy.
    Authors: Andres-Mach
    Int J Mol Sci  2017;18(5):E900
  3. Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
    Authors: Han
    Brain Res  2017;1663:132
  4. Orphan nuclear receptor ERRγ is a key regulator of human fibrinogen gene expression.
    Authors: Zhang
    PLoS One  2017;12(7):e0182141
  5. Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca2+ oscillations in mouse pancreatic acinar cells
    Authors: Huang Et al.
    Scientific Reports  2016;6:29757
  6. The Orphan Nuclear Receptor ERR? Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression
    Authors: Jung Et al.
    PLoS One  2016;11:e0159425
  7. Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain.
    Authors: Rivera Et al.
    Front Cell Neurosci  2015;9:379
  8. Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.
    Authors: Zhou Et al.
    Br J Pharmacol  2015;64:32
  9. Hypothalamic POMC neurons promote cannabinoid-induced feeding.
    Authors: Koch Et al.
    Mol Cell Neurosci  2015;519:45
  10. Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.
    Authors: Gianella-Borradori Et al.
    Bioorg Med Chem  2015;23:241
  11. Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages.
    Authors: Meijerink Et al.
    J Neuroimmune Pharmacol  2015;172:24
  12. △(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.
    Authors: Williams Et al.
    J Neuroendocrinol  2014;9:369
  13. CB1 augments mGluR5 function in medial prefrontal cortical neurons to inhibit amygdala hyperactivity in an arthritis pain model.
    Authors: Ji and Neugebauer
    Eur J Neurosci  2014;39:455
  14. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Nature  2014;17:1943
  15. Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.
    Authors: Benz Et al.
    PLoS One  2013;8:e81675
  16. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.
    Authors: Malenczyk Et al.
    J Biol Chem  2013;288:32685
  17. Opposing roles for cannabinoid receptor type-1 (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.
    Authors: Casarotto Et al.
    Int J Neuropsychopharmacol  2012;37:478
  18. Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks.
    Authors: Gonzalez-Islas Et al.
    J Cell Biol  2012;32:13597
  19. Photoperiodic changes in endocannabinoid levels and energetic responses to altered signalling at CB1 receptors in Siberian hamsters.
    Authors: Ho Et al.
    J Neurosci  2012;24:1030
  20. Desensitization of transient receptor potential ankyrin 1 (TRPA1) by the TRP vanilloid 1-selective cannabinoid arachidonoyl-2 chloroethanolamine.
    Authors: Ruparel Et al.
    Mol Cancer  2011;80:117
  21. Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening.
    Authors: Moaddel Et al.
    Anal Biochem  2011;412:85
  22. Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.
    Authors: Sei Et al.
    PLoS One  2010;5:e10789
  23. Cannabinoid inhibition of macrophage migration to the trans-activating (Tat) protein of HIV-1 is linked to the CB(2) cannabinoid receptor.
    Authors: Raborn and Cabral
    J Pharmacol Exp Ther  2010;333:319
  24. Small intestinal cannabinoid receptor changes following a single colonic insult with oil of mustard in mice.
    Authors: Kimball Et al.
    Front Pharmacol  2010;1:132
  25. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine.
    Authors: Garzón Et al.
    Mol Pain  2009;5:11
  26. Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.
    Authors: Mendiguren and Pineda
    Br J Pharmacol  2009;158:1579
  27. Endogenous cannabinoids induce fever through the activation of CB1 receptors.
    Authors: Fraga Et al.
    Neuropsychopharmacology  2009;157:1494
  28. The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor.
    Authors: Raborn Et al.
    J Neuroimmune Pharmacol  2008;3:117
  29. Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
    Authors: Mathison Et al.
    Br J Pharmacol  2004;142:1247
  30. The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response.
    Authors: Williams Et al.
    Mol Pharmacol  2003;160:481
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