Chemical Name: N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Biological ActivityPotent and highly selective CB1 receptor agonist (Ki = 1.4 nM). Displays >1400-fold selectivity over CB2 receptors. Active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacology of cannabinoid receptor ligands.
Cannabinoid CB1 receptor agonists produce cerebellar dysfunction in mice.
Patel et al.
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).
Hillard et al.
Citations for ACEA
The citations listed below are publications that use Tocris products. Selected citations for ACEA include:
36 Citations: Showing 1 - 10
Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors.
Authors: Diniz Et al.
On the influence of cannabinoids on cell morphology and motility of glioblastoma cells.
Authors: Hohmann Et al.
PLoS One 2019;14:e0212037
Adipocyte OGT governs diet-induced hyperphagia and obesity.
Authors: Li Et al.
Nat Commun 2018;9:5103
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro.
Authors: Balleza-Tapia Et al.
Bidirectional allosteric interactions between cannabinoid receptor 1 (CB1) and DAreceptor 2 long (D2L) heterotetramers.
Eur J Pharmacol 2017;813:66
A long-term treatment with arachidonyl-2''chloroethylamide combined with valproate increases neurogenesis in a mouse PilC model of epilepsy.
Int J Mol Sci 2017;18(5):E900
Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
Brain Res 2017;1663:132
Orphan nuclear receptor ERRγ is a key regulator of human fibrinogen gene expression.
PLoS One 2017;12(7):e0182141
Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca2+ oscillations in mouse pancreatic acinar cells
Authors: Huang Et al.
Scientific Reports 2016;6:29757
The Orphan Nuclear Receptor ERR? Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression
Authors: Jung Et al.
PLoS One 2016;11:e0159425
Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain.
Authors: Rivera Et al.
Front Cell Neurosci 2015;9:379
Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream.
Authors: Zhou Et al.
Br J Pharmacol 2015;64:32
Hypothalamic POMC neurons promote cannabinoid-induced feeding.
Authors: Koch Et al.
Mol Cell Neurosci 2015;519:45
Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.
Authors: Gianella-Borradori Et al.
Bioorg Med Chem 2015;23:241
Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages.
Authors: Meijerink Et al.
J Neuroimmune Pharmacol 2015;172:24
△(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection.
Authors: Williams Et al.
J Neuroendocrinol 2014;9:369
CB1 augments mGluR5 function in medial prefrontal cortical neurons to inhibit amygdala hyperactivity in an arthritis pain model.
Authors: Ji and Neugebauer
Eur J Neurosci 2014;39:455
The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Authors: Sánchez-Blázquez Et al.
Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma.
Authors: Benz Et al.
PLoS One 2013;8:e81675
CB1 cannabinoid receptors couple to focal adhesion kinase to control Ins release.
Authors: Malenczyk Et al.
J Biol Chem 2013;288:32685
Opposing roles for cannabinoid receptor type-1 (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.
Authors: Casarotto Et al.
Int J Neuropsychopharmacol 2012;37:478
Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks.
Authors: Gonzalez-Islas Et al.
J Cell Biol 2012;32:13597
Photoperiodic changes in endocannabinoid levels and energetic responses to altered signalling at CB1 receptors in Siberian hamsters.
Authors: Ho Et al.
J Neurosci 2012;24:1030
Desensitization of transient receptor potential ankyrin 1 (TRPA1) by the TRP vanilloid 1-selective cannabinoid arachidonoyl-2 chloroethanolamine.
Authors: Ruparel Et al.
Mol Cancer 2011;80:117
Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening.
Authors: Moaddel Et al.
Anal Biochem 2011;412:85
Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.
Authors: Sei Et al.
PLoS One 2010;5:e10789
Cannabinoid inhibition of macrophage migration to the trans-activating (Tat) protein of HIV-1 is linked to the CB(2) cannabinoid receptor.
Authors: Raborn and Cabral
J Pharmacol Exp Ther 2010;333:319
Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization.
Authors: Zhang Et al.
Eur J Neurosci 2010;31:225
Small intestinal cannabinoid receptor changes following a single colonic insult with oil of mustard in mice.
Authors: Kimball Et al.
Front Pharmacol 2010;1:132
Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor.
Authors: Garzón Et al.
Mol Pain 2009;5:11
Effect of the CB(1) receptor antagonists rimon. and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.
Authors: Mendiguren and Pineda
Br J Pharmacol 2009;158:1579
Endogenous cannabinoids induce fever through the activation of CB1 receptors.
Authors: Fraga Et al.
The cannabinoid delta-9-tetrahydrocannabinol mediates inhibition of macrophage chemotaxis to RANTES/CCL5: linkage to the CB2 receptor.
Authors: Raborn Et al.
J Neuroimmune Pharmacol 2008;3:117
Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
Authors: Mathison Et al.
Br J Pharmacol 2004;142:1247
The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response.
Authors: Williams Et al.
Mol Pharmacol 2003;160:481
Endocannabinoids protect the rat isolated heart against ischaemia.
Authors: Lépicier Et al.
Br J Pharmacol 2003;139:805
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for ACEA
There are currently no reviews for this product. Be the first to review ACEA and earn rewards!
Have you used ACEA?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image