Acinus Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-76869

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%). Backed by our 100% Guarantee.

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Acinus Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a peptide corresponding to amino acids near the C-terminus of the cleaved active peptide p17, which are identical to those of mouse Acinus. The immunogen is located within amino acids 1050 - 1100 of Acinus. Amino Acid Squence: TRTALHGVKWPQSNPK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

220 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Acinus Antibody - BSA Free

Western Blot: Acinus AntibodyBSA Free [NBP1-76869]

Western Blot: Acinus AntibodyBSA Free [NBP1-76869]

Western Blot: Acinus Antibody [NBP1-76869] - K562 whole cell lysate with Acinus antibody (CP) at 1 ug/ml.
Acinus Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: Acinus Antibody - BSA Free [NBP1-76869] -

Immunocytochemistry/ Immunofluorescence: Acinus Antibody - BSA Free [NBP1-76869] - Immunocytochemistry staining of K562 cells using Acinus antibody at 10 ug/mL.
Acinus Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: Acinus Antibody - BSA Free [NBP1-76869] -

Immunocytochemistry/ Immunofluorescence: Acinus Antibody - BSA Free [NBP1-76869] - Immunofluorescence of Acinus in Hela cells with Acinus antibody at 10 ug/mL.
Acinus Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: Acinus Antibody - BSA Free [NBP1-76869] -

Immunocytochemistry/ Immunofluorescence: Acinus Antibody - BSA Free [NBP1-76869] - Immunofluorescence of Acinus in K562 cells with Acinus antibody at 20 ug/ml.

Green: Acinus Antibody
Blue: DAPI staining

Applications for Acinus Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10 ug/ml

Western Blot

1 ug/ml
Application Notes
An approximate 220 kDa band can be detected in Western Blot.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Acinus

Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS'.

Alternate Names

Acinus, ACN, apoptotic chromatin condensation inducer 1, apoptotic chromatin condensation inducer in the nucleus, fSAP152, functional spliceosome-associated protein 152, KIAA0670DKFZp667N107

Gene Symbol

ACIN1

UniProt

AAD56724 (Human)

Additional Acinus Products

Product Documents for Acinus Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Acinus Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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