Activin RIB/ALK-4 Antibody (S08-8D6)

Name: Activin RIB/ALK-4 Antibody (S08-8D6)
Brand: Novus Biologicals
SKU: NBP3-19558
Price: 559 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-19558

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S08-8D6 expressed in HEK293

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Product Specifications

Immunogen

A synthetic peptide of human Activin RIB/ALK-4 (Uniprot # P36896)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Activin RIB/ALK-4 Antibody (S08-8D6)

Western Blot: Activin RIB/ALK-4 Antibody (S08-8D6) [NBP3-19558]

Western Blot: Activin RIB/ALK-4 Antibody (S08-8D6) [NBP3-19558] - Western blot detection of Activin RIB/ALK-4 in CHO-K1 (Lane 1), Rat Brain (Lane 2) lysates using NBP3-19558 (1:500 diluted). Predicted band size: 57kDa. Observed band size: 57kDa.

Immunocytochemistry/ Immunofluorescence: Activin RIB/ALK-4 Antibody (S08-8D6) [NBP3-19558] -

Immunocytochemistry/ Immunofluorescence: Activin RIB/ALK-4 Antibody (S08-8D6) [NBP3-19558] - Immunofluorescence of Activin RIB/ALK-4 (green) in hela using NBP3-19558 at dilution 1/50, and DAPI(blue)

Applications for Activin RIB/ALK-4 Antibody (S08-8D6)

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:100-1:500

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Activin RIB/ALK-4

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

Long Name

Activin Receptor IB

Alternate Names

ActivinRIB, ACVR1B, ALK-4, ALK4

Gene Symbol

ACVR1B

Additional Activin RIB/ALK-4 Products

Product Documents for Activin RIB/ALK-4 Antibody (S08-8D6)

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Certificate of Analysis

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Product Specific Notices for Activin RIB/ALK-4 Antibody (S08-8D6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Activin Family

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