AdipoR1 Antibody

Novus Biologicals | Catalog # NBP1-28640

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human, Rat

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all AdipoR1 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide (CYAARIPERFFPGKFDIWFQSHQIF) corresponding to aa 317-340 of the C-terminal domain of Human, Mouse and Rat ADPR 1 Receptor

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for AdipoR1 Antibody

Immunohistochemistry: AdipoR1 Antibody [NBP1-28640]

Immunohistochemistry: AdipoR1 Antibody [NBP1-28640]

Immunohistochemistry: AdipoR1 Antibody [NBP1-28640] - Paraffin section of human muscle
Immunohistochemistry: AdipoR1 Antibody [NBP1-28640]

Immunohistochemistry: AdipoR1 Antibody [NBP1-28640]

Immunohistochemistry: AdipoR1 Antibody [NBP1-28640] - Antibody to human AdipoR1 C-terminus on paraffin section of human liver

Applications for AdipoR1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:250

Immunohistochemistry-Paraffin

1:250

Western Blot

1:1000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 1.0 mg/ml BSA

Preservative

0.1% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -80C. Avoid freeze-thaw cycles.

Background: AdipoR1

Acrp30 is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR-. Cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have shown that AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports the conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin. Widely expressed. Highly expressed in skeletal muscle. ADR 1 is expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.

Long Name

Adiponectin Receptor 1

Alternate Names

ACDCR1, CGI45, PAQR1, TESBP1A

Gene Symbol

ADIPOR1

Additional AdipoR1 Products

Product Documents for AdipoR1 Antibody

Certificate of Analysis

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Product Specific Notices for AdipoR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for AdipoR1 Antibody

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Protocols

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