Biological ActivityPotent and selective KV1.3 channel blocker (IC50 values are 0.0019 and 0.65 nM for KV1.3 and KV1.1, respectively). Inhibits CD4+ CCR7- T cell activation. Ameliorates rat experimental autoimmune encephalomyelitis, in a model for multiple sclerosis.
(Modifications: Disulfide bridge: 7 - 27, 13 - 32, 17 - 34)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structural basis of a potent peptide inhibitor designed for KV1.3 channel, a therapeutic target of autoimmune disease.
Han et al.
Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model.
Li et al.
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Product was used on KV1.1 channels to measure the percentage blocking action exhibited against increasing concentration. Concentration action relation was studied on various cell lines expressing Kv 1.1 channels to understand the differences.