ADWX 1

Catalog # Availability Size / Price Qty
4812/100U
Cat.No. 4812 - ADWX 1 | Val-Gly-Ile-Asn-Val-Lys-Cys-Lys-His-Ser-Arg-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Thr-Asn-Gly-Lys-Cys-His-Cys-Thr-Pro-Lys
1 Image
Description: Potent and selective KV1.3 channel blocker
Product Details
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Biological Activity

Potent and selective KV1.3 channel blocker (IC50 values are 0.0019 and 0.65 nM for KV1.3 and KV1.1, respectively). Inhibits CD4+ CCR7- T cell activation. Ameliorates rat experimental autoimmune encephalomyelitis, in a model for multiple sclerosis.

Technical Data

M.Wt:
4071.86
Formula:
C169H281N57O46S7
Sequence:
VGINVKCKHSRQCLKPCKDAGMRFGKCTNGKCHCTPK

(Modifications: Disulfide bridge: 7 - 27, 13 - 32, 17 - 34)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Product Datasheets

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Reconstitution Calculator

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