Potent and selective KV
1.3 channel blocker (IC50
values are 0.0019 and 0.65 nM for KV
1.3 and KV
1.1, respectively). Inhibits CD4+
T cell activation. Ameliorates rat experimental autoimmune encephalomyelitis, in a model for multiple sclerosis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Structural basis of a potent peptide inhibitor designed for KV1.3 channel, a therapeutic target of autoimmune disease.
Han et al.
Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model.
Li et al.