AG 1478 hydrochloride

Tocris Bioscience | Catalog # 1276

Highly potent EGFR-kinase inhibitor
Tocris Bioscience

Key Product Details

Description

Highly potent EGFR-kinase inhibitor

Alternative Names

Tyrphostin AG 1478
View all EGF Receptor Inhibitors »

Product Description

AG 1478 hydrochloride is a potent and selective inhibitor of epidermal growth factor receptor kinase (IC50 values 3 nM for EGFR and > 100 μM for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC50 = 1 μM).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Product Specifications for AG 1478 hydrochloride

Molecular Weight

352.22

Formula

C16H14ClN3O2.HCl

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride

CAS Number

170449-18-0

PubChem ID

3035187

InChI Key

WDJDYIUSDDVWKB-UHFFFAOYSA-N

SMILES

ClC1=CC(NC2=NC=NC3=C2C=C(OC)C(OC)=C3)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.52 10 with gentle warming

Preparing Stock Solutions for AG 1478 hydrochloride

The following data is based on the product molecular weight 352.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.39 mL 141.96 mL 283.91 mL
0.5 mM 5.68 mL 28.39 mL 56.78 mL
1 mM 2.84 mL 14.20 mL 28.39 mL
5 mM 0.57 mL 2.84 mL 5.68 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 33 publications citing the usage of this product.

Product Documents for AG 1478 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AG 1478 hydrochloride

For research use only

Citations for AG 1478 hydrochloride

Customer Reviews for AG 1478 hydrochloride (2)

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2 Customer Ratings
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  • It works great!
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Cancer cells
    Verified Customer | Posted 09/17/2022
    PGE2 secretion was measured in mouse breast cancer cell lines and AG1478 significantly abolished the EGF-induced PGE2 secretion.
    AG 1478 hydrochloride 1276
  • EGFR and MAPK inhibitor
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Hepg2, Huh7
    Verified Customer | Posted 03/10/2020
    serum-free media is working good for me
    Used this inhibitor in 50nm for 24 hours and I found less activation of the MAPK pathway and cell growth and migration
    AG 1478 hydrochloride 1276

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