AG 1478 hydrochloride
Chemical Name: N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine hydrochloride
Biological ActivityPotent and selective inhibitor of epidermal growth factor receptor kinase (IC50 values 3 nM for EGFR and > 100 μM for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro (IC50 = 1 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells.
Eguchi et al.
Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors.
Han et al.
Cancer Res., 1996;56:3859
Tyrosine kinase inhibition: an approach to drug development.
Levitzki and Gazit
Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer.
Puri and Salgia
Citations for AG 1478 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for AG 1478 hydrochloride include:
20 Citations: Showing 1 - 10
Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardialischemia-reperfusion injury.
Nat Commun 2018;9(1):816
FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids.
Authors: Hosseini Et al.
J Cell Sci 2018;131
Epidermal Growth Factor Receptor Signaling Enhances the Proinflammatory Effects of Staphylococcus aureus Gamma-Toxin on the Mucosa.
Authors: Gillman Et al.
Toxins (Basel) 2017;9
Increased NRG1-ErbB4 signaling in human symptomatic epilepsy
Sci Rep 2017;7(1):141
Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination.
Authors: Leonetti Et al.
Mol Neurodegener 2017;12:20
Local Epidermal Growth Factor Receptor Signaling Mediates the Systemic Pathogenic Effects of Staphylococcus aureus Toxic Shock Syndrome
Authors: Breshears Et al.
PLoS One 2016;11:e0158969
Feedback circuitry between miR-218 repression and RTK activation in glioblastoma.
Authors: Mathew Et al.
Cell Death Dis 2015;8:ra42
Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.
Authors: Bertrand Et al.
Sci Rep 2015;6:e1924
Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.
Authors: Ledonne Et al.
Mol Psychiatry 2015;20:959
TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
Authors: Pandya and Pillai
Sci Signal 2014;12:47
Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-DA-like G protein-coupled receptor.
Authors: Bayliss and Evans
PLoS One 2013;8:e80833
EMT-induced stemness and tumorigenicity are fueled by the EGFR/Ras pathway.
Authors: Voon Et al.
PLoS One 2013;8:e70427
Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.
Authors: Akhtar Et al.
PLoS One 2013;8:e67813
Profiling epidermal growth factor receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology.
Authors: Ayoub Et al.
PLoS One 2013;8:e64672
A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).
Authors: Breshears Et al.
J Biol Chem 2012;287:32578
DA-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF.
Authors: O'Keeffe Et al.
Proc Natl Acad Sci U S A 2009;106:8754
Resonant waveguide grating biosensor for living cell sensing.
Authors: Fang Et al.
Biophys J 2006;91:1925
Rapid estrogenic regulation of extracellular signal- regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A.
Authors: Belcher Et al.
The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-OE and phytoestrogens in breast cancer cells.
Authors: Maggiolini Et al.
J Biol Chem 2004;279:27008
IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation.
Authors: Atherton Et al.
Am J Physiol Lung Cell Mol Physiol 2003;285:L730
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Reviews for AG 1478 hydrochloride
Average Rating: 4 (Based on 1 Review)
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Used this inhibitor in 50nm for 24 hours and I found less activation of the MAPK pathway and cell growth and migration