Potent and selective inhibitor of epidermal growth factor receptor kinase (IC50
values 3 nM for EGFR and > 100 μ
M for ErbB2 and PDGFR). Inhibits proliferation of NCI-H2170 NSCLC cells in vitro
= 1 μ
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Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells.
Eguchi et al.
Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors.
Han et al.
Cancer Res., 1996;56:3859
Tyrosine kinase inhibition: an approach to drug development.
Levitzki and Gazit
Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer.
Puri and Salgia
The citations listed below are publications that use Tocris products. Selected citations for AG 1478 hydrochloride include:
Showing Results 1 - 10 of 12