AG 18

  ( 1 citations )    
Product Datasheet
Catalog Number:0493
Alternate Names:RG-50810, Tyrphostin A23
Chemical Name:[(3,4-Dihydroxyphenyl)methylene]-propenedinitrile
Product Details
Citations (1)
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Biological Activity
Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC50 values are 35 and 25 μM respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling.
Technical Data
  • M.Wt:
    186.17
  • Formula:
    C10H6N2O2
  • Storage:
    Desiccate at +4°C
  • CAS No:
    118409-57-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AG 18 include:

1 Citations: Showing 1 - 1

  1. Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries.
    Authors: Villalba Et al.
    Am J Physiol Heart Circ Physiol  2007;292:H1157

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