AG 18

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.
   Gazit et al.
   Science, 1988;242:933
3. Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation.
   Gazit et al.
   J.Biol.Chem., 1989;264:14503
4. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.
   Gazit et al.
   J.Med.Chem., 1989;32:2344
5. Tyrosine kinase inhibition: an approach to drug development.
   Levitzki and Gazit
   Science, 1995;267:1782
6. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling.
   Soltoff
   J.Biol.Chem., 2004;279:10910

Product Datasheets