Catalog Number: 0619
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
Biological Activity
Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM). Selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in ethanol and to 50 mM in DMSO
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes.
    Ben-Bassat et al.
    J.Pharmacol.Exp.Ther., 1999;290:1442
  2. Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
    Gazit et al.
    J.Med.Chem., 1991;34:1896
  3. Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts.
    Tomlins et al.
    Exp.Cell Res., 2005;308:439
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