Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50
= 0.7 μ
M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC50
values are 42, 6 and > 100 μ
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All Tocris products are intended for laboratory research use only.
Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes.
Ben-Bassat et al.
Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Gazit et al.
Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts.
Tomlins et al.
Exp.Cell Res., 2005;308:439