Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50
= 1.1 μ
M). Selective over ErbB2 (IC50
> 500 μ
Soluble to 30 mM in DMSO
Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Secondary dimerization between members of the epidermal growth factor receptor family.
Gamett et al.
Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Gazit et al.