Catalog Number: 0616
Alternate Names: Tyrphostin AG 556
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide
Biological Activity
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 1.1 μM). Selective over ErbB2 (IC50 > 500 μM).
Technical Data
  • M.Wt:
    336.39
  • Formula:
    C20H20N2O3
  • Solubility:
    Soluble to 30 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    133550-41-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Secondary dimerization between members of the epidermal growth factor receptor family.
    Gamett et al.
    J.Biol.Chem., 1997;272:12052
  2. Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
    Gazit et al.
    J.Med.Chem., 1991;34:1896

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